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BMP9 通过上调 lncRNA UCA1 促进膀胱癌细胞的增殖和迁移。

BMP9 Promotes the Proliferation and Migration of Bladder Cancer Cells through Up-Regulating lncRNA UCA1.

机构信息

Key Laboratory of Diagnostic Medicine Designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing 400000, China.

Molecular Oncology Laboratory, Department of Surgery, University of Chicago Medical Center, Chicago, IL 60637, USA.

出版信息

Int J Mol Sci. 2018 Apr 8;19(4):1116. doi: 10.3390/ijms19041116.

DOI:10.3390/ijms19041116
PMID:29642505
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5979556/
Abstract

As the most common malignant tumor of the urinary system worldwide, the bladder tumor has a high mortality rate, which is mainly due to its onset of concealment. Therefore, research into novel diagnostic markers and treatment of bladder cancer is urgently needed. BMP9 (Bone morphogenetic protein 9) is a member of BMP, which belongs to the TGF-β (transforming growth factor-β) superfamily. It has been associated with multiple tumors. We found that BMP9 is highly expressed in bladder cancer cells and it could significantly promote the proliferation and migration of bladder cancer cells. In the study of the mechanism of this effect, we found that BMP9 can increase the expression of lncRNA () through phosphorylated AKT. The promoting effect of BMP9 on bladder cancer cells was rescued after interfering with in BMP9 overexpressed bladder cancer cells both in vitro and in vivo. Our research confirms that BMP9 promotes the proliferation and migration of bladder cancer cells through up-regulated lncRNA . It also shows that BMP9 is a novel diagnostic marker and a potential therapeutic target in bladder cancer.

摘要

作为全球最常见的泌尿系统恶性肿瘤，膀胱癌死亡率较高，主要与其起病隐匿有关。因此，迫切需要研究新型膀胱癌的诊断标志物和治疗方法。BMP9（骨形态发生蛋白 9）是 BMP 家族的成员，属于 TGF-β（转化生长因子-β）超家族。它与多种肿瘤有关。我们发现 BMP9 在膀胱癌细胞中高表达，并且可以显著促进膀胱癌细胞的增殖和迁移。在研究这种作用的机制时，我们发现 BMP9 可以通过磷酸化 AKT 增加 lncRNA （）的表达。在体外和体内实验中，干扰 BMP9 过表达膀胱癌细胞中的 后，BMP9 对膀胱癌细胞的促进作用得到挽救。我们的研究证实，BMP9 通过上调 lncRNA 促进膀胱癌细胞的增殖和迁移。它还表明，BMP9 是膀胱癌的一种新型诊断标志物和潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/4babad06c859/ijms-19-01116-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/478b194688f5/ijms-19-01116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/81622cc43528/ijms-19-01116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/4fdd44771191/ijms-19-01116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/d2b733c7aa3d/ijms-19-01116-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/4babad06c859/ijms-19-01116-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/478b194688f5/ijms-19-01116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/81622cc43528/ijms-19-01116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/4fdd44771191/ijms-19-01116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/d2b733c7aa3d/ijms-19-01116-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e55/5979556/4babad06c859/ijms-19-01116-g005.jpg

相似文献

[1]
BMP9 Promotes the Proliferation and Migration of Bladder Cancer Cells through Up-Regulating lncRNA UCA1.

Int J Mol Sci. 2018-4-8

[2]
Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1.

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[3]
Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1α-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion.

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[4]
C/EBPβ promotes the viability of human bladder cancer cell by contributing to the transcription of bladder cancer specific lncRNA UCA1.

Biochem Biophys Res Commun. 2018-10-28

[5]
Inhibition of long non-coding RNA UCA1 by CRISPR/Cas9 attenuated malignant phenotypes of bladder cancer.

Oncotarget. 2017-2-7

[6]
LncRNA UCA1 Promotes Mitochondrial Function of Bladder Cancer via the MiR-195/ARL2 Signaling Pathway.

Cell Physiol Biochem. 2017

[7]
Long non-coding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells.

Oncol Rep. 2014-9

[8]
Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling.

FEBS J. 2014-2-20

[9]
Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein α contributes to bladder cancer cell growth and reduced apoptosis.

Oncol Rep. 2014-5

[10]
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引用本文的文献

[1]
Sonic Hedgehog potentiates BMP9-induced osteogenic differentiation of mesenchymal stem cells.

Genes Dis. 2024-4-14

[2]
The role of curcumin in modulating circular RNAs and long non-coding RNAs in cancer.

Clin Transl Oncol. 2025-6

[3]
Bladder cancer: non-coding RNAs and exosomal non-coding RNAs.

Funct Integr Genomics. 2024-8-31

[4]
p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway.

Med Oncol. 2024-5-31

[5]
New Perspectives on the Role of Liquid Biopsy in Bladder Cancer: Applicability to Precision Medicine.

Cancers (Basel). 2024-2-16

[6]
BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway.

BMC Mol Cell Biol. 2023-8-7

[7]
Bone morphogenetic protein-9 promotes the proliferation of non-small cell lung cancer cells by activating PI3K/Akt and Smad1/5 pathways.

RSC Adv. 2020-2-19

[8]
Novel Pathways for Targeting Tumor Angiogenesis in Metastatic Breast Cancer.

Front Oncol. 2021-12-3

[9]
Identification of liver-derived bone morphogenetic protein (BMP)-9 as a potential new candidate for treatment of colorectal cancer.

J Cell Mol Med. 2022-1

[10]
Biological functions and clinical significance of long noncoding RNAs in bladder cancer.

Cell Death Discov. 2021-10-5

本文引用的文献

[1]
LncRNA HULC promotes epithelial and smooth-muscle-like differentiation of adipose-derived stem cells by upregulation of BMP9.

Pharmazie. 2018-1-2

[2]
Long non-coding RNA expression in bladder cancer.

Biophys Rev. 2018-8

[3]
LncRNA MALAT1 Inhibits Apoptosis and Promotes Invasion by Antagonizing miR-125b in Bladder Cancer Cells.

J Cancer. 2017-10-17

[4]
LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR-143/HMGB1 pathway.

Oncol Lett. 2017-11

[5]
Long non-coding RNA HNF1A-AS1 promotes proliferation and suppresses apoptosis of bladder cancer cells through upregulating Bcl-2.

Oncotarget. 2017-9-8

[6]
RUNX3 plays an important role in mediating the BMP9-induced osteogenic differentiation of mesenchymal stem cells.

Int J Mol Med. 2017-9-27

[7]
Prevention of bladder cancer incidence and recurrence: tobacco use.

Curr Opin Urol. 2018-1

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Inhibitory effects of BMP9 on breast cancer cells by regulating their interaction with pre-adipocytes/adipocytes.

Oncotarget. 2017-5-30

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CA Cancer J Clin. 2017-1-5

[10]
Follicle-Stimulating Hormone β-Subunit Potentiates Bone Morphogenetic Protein 9-Induced Osteogenic Differentiation in Mouse Embryonic Fibroblasts.

J Cell Biochem. 2017-7

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