Yılmaz Mücahid, Kayançiçek Hidayet
Department of Cardiology, Elazığ Education and Research Hospital, Elazığ 23200, Turkey.
Department of Cardiology, Elazığ Medical Park Hospital (Affiliated to Istinye University), Elazığ 23040, Turkey.
J Clin Med. 2018 Apr 10;7(4):76. doi: 10.3390/jcm7040076.
The adverse effects of smoking in various pathologies are mediated by its effects on the inflammatory system. The monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) has recently emerged as an indicator of inflammation. We aimed to investigate the relationship between MHR and cigarette smoking.
Three hundred and ninety seven consecutive participants who smoke and 515 healthy subjects with no history of smoking enrolled in the study. Complete blood count parameters and lipid profile were analyzed in all study participants. Smoking habits were calculated as pack.years and number of cigarettes smoked per day.
MHR levels were significantly higher in smokers compared to non-smokers (respectively, 15.71 (12.02-20.00) and 11.17 (8.50-14.16), < 0.0001)). Pearson's correlation analysis revealed a weak but positive correlation between pack.year and MHR in the smokers group, and there was a moderate positive correlation between the number of cigarettes smoked daily and MHR in the group. In receiver operating characteristics (ROC) analyses, it was determined that a MHR value >13.00 measured in smoker participants at application had a predictive specificity of 66.6% and sensitivity of 70.0% for smoking (area under the curve [AUC] 0.729, 95% CI 0.696, 0.762; < 0.0001).
Elevated MHR is associated with cigarette smoking and may be a useful indicator of a systemic inflammatory response in smokers. Smoker participants who have high MHR levels can easily be identified during routine complete blood count (CBC) analysis and could possibly benefit from preventive treatment.
吸烟在各种病理状态下的不良影响是通过其对炎症系统的作用介导的。单核细胞与高密度脂蛋白胆固醇（HDL-C）的比值（MHR）最近已成为一种炎症指标。我们旨在研究MHR与吸烟之间的关系。
397名连续入选的吸烟者和515名无吸烟史的健康受试者参与了本研究。对所有研究参与者的全血细胞计数参数和血脂谱进行了分析。吸烟习惯以包年数和每日吸烟支数来计算。
吸烟者的MHR水平显著高于非吸烟者（分别为15.71（12.02 - 20.00）和11.17（8.50 - 14.16），<0.0001））。Pearson相关分析显示，吸烟者组中包年数与MHR之间存在弱但正相关，且该组中每日吸烟支数与MHR之间存在中度正相关。在受试者工作特征（ROC）分析中，确定在应用时吸烟者中测得的MHR值>13.00对吸烟具有预测特异性为66.6%，敏感性为70.0%（曲线下面积[AUC] 0.729，95%可信区间0.696，0.762；<0.0001）。
MHR升高与吸烟有关，可能是吸烟者全身炎症反应的一个有用指标。MHR水平高的吸烟者在常规全血细胞计数（CBC）分析过程中很容易被识别，并且可能从预防性治疗中获益。
