Su Shan-Shan, Zheng Guo-Qi, Yin Wen-Jie, Liang Yu-Fei, Liu Ying-Ying, Song Hui, Sun Ning-Ning, Yang Yu-Xin
Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, China.
Gastroenterol Res Pract. 2018 Feb 15;2018:2619526. doi: 10.1155/2018/2619526. eCollection 2018.
To determine effects of the biochemical and cytological properties of blood, serum, and ascites on survival of patients with malignant peritoneal effusion (MPeE), including malignant peritoneal mesothelioma (MPeM) and peritoneal carcinomatosis (PC), we conducted a retrospective study of patients with MPeE and healthy controls. Potential prognostic factors were identified as follows: age, sex, blood neutrophil-to-lymphocyte ratio (NLR), serum parameters, ascites parameters, serum-ascites albumin gradient, and the ascites-serum LDH ratio. Compared to those of the control group, serum albumin levels were significantly lower, and the NLR and serum LDH levels were significantly higher in the MPeE group. Overall survival (OS) was longer in patients with MPeM compared to that in patients with PC. Compared with patients in the MPeM, patients with PC had higher NLRs, ascites glucose levels, serum-ascites albumin gradients, and serum LDH levels. In contrast, their ascites albumin levels and ascites-serum LDH ratios were lower. Univariate analyses indicated that the NLR, serum LDH levels, ascites LDH levels, ascites coenocyte levels, and the ascites coenocyte-to-monocyte ratios affected the OS. Multivariate analyses identified only serum and ascites LDH levels as independent prognostic factors.
为了确定血液、血清和腹水的生化及细胞学特性对恶性腹腔积液（MPeE，包括恶性腹膜间皮瘤（MPeM）和腹膜转移癌（PC））患者生存的影响，我们对MPeE患者和健康对照进行了一项回顾性研究。潜在的预后因素确定如下：年龄、性别、血液中性粒细胞与淋巴细胞比值（NLR）、血清参数、腹水参数、血清-腹水白蛋白梯度以及腹水-血清乳酸脱氢酶比值。与对照组相比，MPeE组血清白蛋白水平显著降低，NLR和血清乳酸脱氢酶水平显著升高。MPeM患者的总生存期（OS）比PC患者更长。与MPeM患者相比，PC患者的NLR、腹水葡萄糖水平、血清-腹水白蛋白梯度和血清乳酸脱氢酶水平更高。相反，他们的腹水白蛋白水平和腹水-血清乳酸脱氢酶比值更低。单因素分析表明，NLR、血清乳酸脱氢酶水平、腹水乳酸脱氢酶水平、腹水多核细胞水平以及腹水多核细胞与单核细胞比值影响OS。多因素分析仅确定血清和腹水乳酸脱氢酶水平为独立预后因素。
