表皮生长因子受体（EGFR）和磷酸酶及张力蛋白同源物（PTEN）表达以及血小板与淋巴细胞比率（PLR）和中性粒细胞与淋巴细胞比率（NLR）对预测上皮样恶性腹膜间皮瘤预后的意义
Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma.
作者信息
Liang Yufei, Zheng Guoqi, Yin Wenjie, Song Hui, Li Chunying, Tian Liang, Yang Dongliang
机构信息
Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, China.
Department of Pathology, Cangzhou Central Hospital, Cangzhou, Hebei 061001, China.
出版信息
Gastroenterol Res Pract. 2019 Feb 4;2019:7103915. doi: 10.1155/2019/7103915. eCollection 2019.
OBJECTIVE
The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM).
METHODS
33 patients of pathologically diagnosed epithelioid MPeM tissues were analyzed using immunohistochemistry to detect EGFR and PTEN; the PLR and NLR were determined by using a routine blood test. We analyzed the relationships of these markers to age, sex, asbestos exposure, elevated platelet count, ascites, and clinical stage.
RESULTS
EGFR and PTEN expressions were positive in 22 (66.67%) and 7 (21.21%) epithelioid MPeM patients, respectively. However, these two markers as well as PLR and NLR were not significantly associated with age, sex, asbestos exposure, elevated platelet counts, ascites, and clinical stage ( > 0.05). The correlation between EGFR and PTEN was negative ( = -0.577, < 0.001), but the correlation between NLR and PLR was positive ( = 0.456, = 0.008). The median survival of all patients was 6 months. In univariate analysis, PTEN ( < 0.001), PLR ( = 0.014), and NLR ( = 0.015) affected the overall survival. Multivariate analysis revealed that PTEN and PLR were validated as predictive for overall survival of epithelioid MPeM (HR = 0.070, = 0.001, and HR = 3.379, = 0.007, respectively).
CONCLUSION
On the basis of these results, it is suggested that PTEN and PLR are risk factors for the prognosis of epithelioid MPeM, which may be targets for selective therapies and improve the outcomes of patients with epithelioid MPeM.
目的
本研究旨在调查表皮生长因子受体（EGFR）和第10号染色体缺失的磷酸酶及张力蛋白同源物（PTEN）在组织中的表达，并检测血清血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR），以评估上皮样恶性腹膜间皮瘤（MPeM）患者的预后因素。
方法
对33例经病理诊断的上皮样MPeM组织患者进行免疫组织化学分析，以检测EGFR和PTEN；通过常规血液检测确定PLR和NLR。我们分析了这些标志物与年龄、性别、石棉暴露、血小板计数升高、腹水和临床分期之间的关系。
结果
EGFR和PTEN表达在22例（66.67%）和7例（21.21%）上皮样MPeM患者中呈阳性。然而，这两种标志物以及PLR和NLR与年龄、性别、石棉暴露、血小板计数升高、腹水和临床分期均无显著相关性（P>0.05）。EGFR与PTEN之间的相关性为负（r=-0.577，P<0.001），但NLR与PLR之间的相关性为正（r=0.456，P=0.008）。所有患者的中位生存期为6个月。单因素分析显示，PTEN（P<0.001）、PLR（P=0.014）和NLR（P=0.015）影响总生存期。多因素分析显示，PTEN和PLR被证实可预测上皮样MPeM的总生存期（风险比分别为0.070，P=0.001和3.379，P=0.007）。
结论
基于这些结果，提示PTEN和PLR是上皮样MPeM预后的危险因素，可能成为选择性治疗的靶点并改善上皮样MPeM患者的预后。
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