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仿生矿化胶原人工骨泥用于跟骨骨折骨重建的临床观察

Clinical observation of biomimetic mineralized collagen artificial bone putty for bone reconstruction of calcaneus fracture.

作者信息

Pan Yong-Xiong, Yang Guang-Gang, Li Zhong-Wan, Shi Zhong-Min, Sun Zhan-Dong

机构信息

Department of Foot and Ankle Orthopedics, Guangzhou Orthopedic Hospital, Guangzhou 510045, China and.

Department of Foot and Ankle Orthopedics, Shanghai Sixth People's Hospital, Shanghai 200233, China.

出版信息

Regen Biomater. 2018 Mar;5(2):61-67. doi: 10.1093/rb/rbx033. Epub 2018 Feb 8.

DOI:10.1093/rb/rbx033
PMID:29644087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5888141/
Abstract

This study investigated clinical outcomes of biomimetic mineralized collagen artificial bone putty for bone reconstruction in the treatment of calcaneus fracture. Sixty cases of calcaneal fractures surgically treated with open reduction and internal fixation in our hospital from June 2014-2015 were chosen and randomly divided into two groups, including 30 cases treated with biomimetic mineralized collagen artificial bone putty as treatment group, and 30 cases treated with autogenous ilia as control group. The average follow-up time was 17.2 ± 3.0 months. The results showed that the surgery duration and postoperative drainage volume of treatment group were significantly lower than control group; there were no statistically significant differences in the fracture healing time, American Orthopaedic Foot and Ankle Society scores at 3 and 12 months after surgery, Böhler's angle, Gissane's angle and height of calcaneus between the two groups. There were no significant differences in wound complication and reject reaction between the two groups, while significant difference in donor site complication. As a conclusion, the implantation of biomimetic mineralized collagen artificial bone putty in the open reduction of calcaneal fracture resulted in reliable effect and less complications, which is suitable for clinical applications in the treatment of bone defect in calcaneal fractures.

摘要

本研究探讨了仿生矿化胶原人工骨泥在跟骨骨折治疗中用于骨重建的临床疗效。选取2014年6月至2015年在我院接受切开复位内固定手术治疗的60例跟骨骨折患者，随机分为两组，其中30例采用仿生矿化胶原人工骨泥治疗作为治疗组，30例采用自体髂骨治疗作为对照组。平均随访时间为17.2±3.0个月。结果显示，治疗组的手术时间和术后引流量显著低于对照组；两组在骨折愈合时间、术后3个月和12个月的美国矫形足踝协会评分、跟骨Böhler角、Gissane角及跟骨高度方面差异无统计学意义。两组在伤口并发症和排斥反应方面无显著差异，但供区并发症有显著差异。结论是，仿生矿化胶原人工骨泥植入跟骨骨折切开复位中效果可靠，并发症少，适用于跟骨骨折骨缺损治疗的临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/c98ff62757e0/rbx033f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/9400e98c2ea9/rbx033f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/8205a7642ad6/rbx033f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/ff52a9491064/rbx033f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/e233251131fc/rbx033f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/c98ff62757e0/rbx033f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/9400e98c2ea9/rbx033f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/8205a7642ad6/rbx033f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/ff52a9491064/rbx033f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/e233251131fc/rbx033f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34a8/5888141/c98ff62757e0/rbx033f5.jpg

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