College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, PR China.
Med-X Center for Materials, Sichuan University, Chengdu, PR China.
Int J Oral Sci. 2021 Dec 7;13(1):42. doi: 10.1038/s41368-021-00147-z.
Biomineralization is the process by which organisms form mineralized tissues with hierarchical structures and excellent properties, including the bones and teeth in vertebrates. The underlying mechanisms and pathways of biomineralization provide inspiration for designing and constructing materials to repair hard tissues. In particular, the formation processes of minerals can be partly replicated by utilizing bioinspired artificial materials to mimic the functions of biomolecules or stabilize intermediate mineral phases involved in biomineralization. Here, we review recent advances in biomineralization-inspired materials developed for hard tissue repair. Biomineralization-inspired materials are categorized into different types based on their specific applications, which include bone repair, dentin remineralization, and enamel remineralization. Finally, the advantages and limitations of these materials are summarized, and several perspectives on future directions are discussed.
生物矿化是生物体形成具有层次结构和优异性能的矿化组织的过程，包括脊椎动物的骨骼和牙齿。生物矿化的潜在机制和途径为设计和构建修复硬组织的材料提供了灵感。特别是，通过利用生物启发的人工材料来模拟生物分子的功能或稳定参与生物矿化的中间矿物相，可以部分复制矿物质的形成过程。在这里，我们综述了用于硬组织修复的受生物矿化启发的材料的最新进展。受生物矿化启发的材料根据其特定应用分为不同类型，包括骨修复、牙本质再矿化和牙釉质再矿化。最后，总结了这些材料的优缺点，并讨论了未来的几个发展方向。
