Chiti Maria C, Donnez Jacques, Amorim Christiani A, Dolmans Marie-Madeleine
Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.
Society for Research into Infertility, Brussels, Belgium.
Minerva Ginecol. 2018 Aug;70(4):444-455. doi: 10.23736/S0026-4784.18.04231-4. Epub 2018 Apr 11.
Cryopreservation and transplantation of ovarian tissue has proved to restore both endocrine and reproductive functions in cancer patients. However, women with a high risk of ovarian involvement cannot undergo ovarian tissue transplantation due to possible recurrence of the disease. Therefore, different teams worldwide are now working on the development of experimental strategies, like the transplantable artificial ovary (TAO), with the noble goal to offer to these patients hope for future conception. This article discusses some essential points for the creation of a TAO and reviews the latest progress made.
卵巢组织的冷冻保存和移植已被证明可恢复癌症患者的内分泌和生殖功能。然而，卵巢受累风险高的女性由于疾病可能复发而无法进行卵巢组织移植。因此，世界各地的不同团队目前正在致力于开发实验性策略，如可移植人工卵巢（TAO），其崇高目标是为这些患者提供未来受孕的希望。本文讨论了创建TAO的一些要点，并综述了最新进展。
