Division of Reproductive Endocrinology and Infertility, Fertility and Advanced Reproductive Medicine Assisted Reproductive Technologies Program, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Assist Reprod Genet. 2021 Oct;38(10):2507-2517. doi: 10.1007/s10815-021-02246-6. Epub 2021 Jun 7.
In assisted reproductive technology treatment, diminished ovarian reserve (DOR) is a condition of utmost clinical and scientific relevance because of its negative influence on patient outcomes. The current methods of infertility treatment may be unsuitable for many women with DOR, which support the need for development of additional approaches to achieve fertility restoration. Various techniques have been tried to improve the quality and increase the quantity of oocytes in DOR patients, including mitochondrial transfer, activation of primordial follicles, in vitro culture of follicles, and regeneration of oocytes from various stem cells. Herein, we review the science behind these experimental reproductive technologies and their potential use to date in clinical studies for infertility treatment in women with DOR.
在辅助生殖技术治疗中，卵巢储备功能降低（DOR）是一种极具临床和科学意义的疾病，因为它对患者结局有负面影响。目前的不孕治疗方法可能不适合许多 DOR 患者，这支持需要开发额外的方法来实现生育力恢复。已经尝试了各种技术来改善 DOR 患者卵母细胞的质量和数量，包括线粒体转移、原始卵泡的激活、卵泡的体外培养以及各种干细胞来源的卵母细胞的再生。在此，我们回顾了这些实验性生殖技术背后的科学原理及其迄今为止在 DOR 女性不孕症临床研究中的潜在用途。
