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浣熊乳中寡糖的化学结构。

Chemical structures of oligosaccharides in milk of the raccoon (Procyon lotor).

机构信息

Department of Food Science, Obihiro University of Agriculture & Veterinary Medicine, Obihiro, Hokkaido, 080-8555, Japan.

The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate, 020-8550, Japan.

出版信息

Glycoconj J. 2018 Jun;35(3):275-286. doi: 10.1007/s10719-018-9821-z. Epub 2018 Apr 11.

DOI:10.1007/s10719-018-9821-z
PMID:29644514
Abstract

In this study on milk saccharides of the raccoon (Procyonidae: Carnivora), free lactose was found to be a minor constituent among a variety of neutral and acidic oligosaccharides, which predominated over lactose. The milk oligosaccharides were isolated from the carbohydrate fractions of each of four samples of raccoon milk and their chemical structures determined by H-NMR and MALDI-TOF mass spectroscopies. The structures of the four neutral milk oligosaccharides were Fuc(α1-2)Gal(β1-4)Glc (2'-fucosyllactose), Fuc(α1-2)Gal(β1-4)GlcNAc(β1-3)Gal(β1-4)Glc (lacto-N-fucopentaose IV), Fuc(α1-2)Gal(β1-4)GlcNAc(β1-3)Gal(β1-4)GlcNAc(β1-3)Gal(β1-4)Glc (fucosyl para lacto-N-neohexaose) and Fuc(α1-2)Gal(β1-4)GlcNAc(β1-3)[Fuc(α1-2)Gal(β1-4)GlcNAc(β1-6)]Gal(β1-4)Glc (difucosyl lacto-N-neohexaose). No type I oligosaccharides, which contain Gal(β1-3)GlcNAc units, were detected, but type 2 saccharides, which contain Gal(β1-4)GlcNAc units were present. The monosaccharide compositions of two of the acidic oligosaccharides were [Neu5Ac][Hex][HexNAc][deoxy Hex], while those of another two were [Neu5Ac][Hex][HexNAc][deoxy Hex] These acidic oligosaccharides contained α(2-3) or α(2-6) linked Neu5Ac, non reducing α(1-2) linked Fuc, poly N-acetyllactosamine (Gal(β1-4)GlcNAc) and reducing lactose.

摘要

在这项关于浣熊（浣熊科：食肉目）乳糖果糖的研究中，游离乳糖被发现是各种中性和酸性低聚糖中的次要成分，这些低聚糖的含量超过了乳糖。从四种浣熊乳的碳水化合物部分分离出乳寡糖，并通过 H-NMR 和 MALDI-TOF 质谱法确定其化学结构。四种中性乳寡糖的结构为 Fuc(α1-2)Gal(β1-4)Glc(2'-岩藻糖基乳糖）、Fuc(α1-2)Gal(β1-4)GlcNAc(β1-3)Gal(β1-4)Glc(乳糖-N-岩藻五糖 IV）、Fuc(α1-2)Gal(β1-4)GlcNAc(β1-3)Gal(β1-4)GlcNAc(β1-3)Gal(β1-4)Glc(岩藻糖基副乳糖-N-新六糖）和 Fuc(α1-2)Gal(β1-4)GlcNAc(β1-3)[Fuc(α1-2)Gal(β1-4)GlcNAc(β1-6)]Gal(β1-4)Glc(双岩藻糖基乳糖-N-新六糖）。未检测到含有 Gal(β1-3)GlcNAc 单元的 I 型寡糖，但存在含有 Gal(β1-4)GlcNAc 单元的 II 型糖。两种酸性寡糖的单糖组成分别为[Neu5Ac][Hex][HexNAc][脱氧 Hex]，另外两种的单糖组成为[Neu5Ac][Hex][HexNAc][脱氧 Hex]。这些酸性寡糖含有α(2-3)或α(2-6)连接的 Neu5Ac、非还原的α(1-2)连接的 Fuc、多 N-乙酰乳糖胺（Gal(β1-4)GlcNAc)和还原的乳糖。

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