Zhao Lin, Sun Lin, Yang KunQi, Zhang ZengLei, Li ZuoZhi, Wang Man, Zhou XianLiang, Zeng Yan, Yang WeiXian
Department of Integrative Medicine Cardiology, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Beijing, China.
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167, Beilishi Road, Beijing, China.
BMC Endocr Disord. 2025 Jul 14;25(1):174. doi: 10.1186/s12902-025-01996-z.
There is an increased risk of diabetes and cardiovascular disease among patients with psoriasis. However, whether diabetes affects the cardiovascular adverse events in patients with psoriasis who have suffered from coronary artery disease remains unclear. This study aimed to explore the prognostic role of diabetes in this particular population.
This single-center, retrospective cohort study included all consecutive adult patients with psoriasis and coronary artery disease admitted at our hospital between January 2017 and May 2022. Clinical records were collected and compared between patients with and without diabetes. Survival curves were derived using Kaplan-Meier methods. Multivariable Cox regression was used to control potential confounding.
This study included 305 participants, including 147 patients (48.2%) with diabetes. Patients with diabetes were more likely to have hypertension (p = 0.045), peripheral vascular disease (p = 0.043) and the history of stroke (p = 0.041). Patients with diabetes also had higher levels of low-density lipoprotein cholesterol (p = 0.039) and homocysteine (p = 0.006). After a median follow-up of 36 months, patients with diabetes had a higher incidence of major adverse cardiovascular events (MACE) than patients without diabetes (p = 0.032). According to the results of the Cox regression analysis, only diabetes (p = 0.039) was associated with MACE. The subgroup analysis showed that diabetes was associated with MACE, especially in male patients (p = 0.008) and those without chronic kidney disease (p = 0.021).
In patients with psoriasis and coronary artery disease, diabetes is independently linked with MACE. These findings will help the risk assessment for patients with psoriasis and coronary artery disease.
银屑病患者患糖尿病和心血管疾病的风险增加。然而，糖尿病是否会影响患有冠状动脉疾病的银屑病患者的心血管不良事件仍不清楚。本研究旨在探讨糖尿病在这一特定人群中的预后作用。
这项单中心回顾性队列研究纳入了2017年1月至2022年5月期间在我院连续收治的所有成年银屑病合并冠状动脉疾病患者。收集并比较了有糖尿病和无糖尿病患者的临床记录。采用Kaplan-Meier方法绘制生存曲线。使用多变量Cox回归来控制潜在的混杂因素。
本研究纳入了305名参与者，其中147名患者（48.2%）患有糖尿病。糖尿病患者更有可能患有高血压（p = 0.045）、外周血管疾病（p = 0.043）和中风病史（p = 0.041）。糖尿病患者的低密度脂蛋白胆固醇（p = 0.039）和同型半胱氨酸水平也更高（p = 0.006）。中位随访36个月后，糖尿病患者的主要不良心血管事件（MACE）发生率高于无糖尿病患者（p = 0.032）。根据Cox回归分析结果，只有糖尿病（p = 0.039）与MACE相关。亚组分析表明，糖尿病与MACE相关，尤其是在男性患者（p = 0.008）和无慢性肾脏病的患者中（p = 0.021）。
在银屑病合并冠状动脉疾病患者中，糖尿病与MACE独立相关。这些发现将有助于对银屑病合并冠状动脉疾病患者进行风险评估。
