Yüksel Rabia Nazik, Ertek Irem Ekmekci, Dikmen Asiye Uğraş, Göka Erol
a Department of Psychiatry , Numune Education and Research Hospital , Ankara , Turkey.
b Department of Psychiatry , Gazi University Medical Faculty , Ankara , Turkey.
Nord J Psychiatry. 2018 Jul;72(5):336-340. doi: 10.1080/08039488.2018.1458899. Epub 2018 Apr 12.
Immunological and inflammatory mechanisms play an important role in schizophrenia. In the literature, there are studies investigating neutrophil-lymphocyte ratio (NLR) association with schizophrenia.
The purpose of this study was to compare NLR values between patients with schizophrenia and healthy controls. In addition, the study aimed to investigate the relationship between NLR and disease severity and some metabolic/inflammatory parameters.
Fifty-two patients diagnosed with schzophrenia and 53 healthy controls were included in the study. A socio-demographic information form was filled out by the clinician. Height, body weight, waist and hip circumference and blood pressure values of each patient were measured. Severity of disease was assessed by positive and negative syndrome scale (PANSS) and clinical global impression-severity scale (CGI-S). Complete blood count was performed to both patient and control groups. Fasting blood glucose, insulin, HbA1c, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride, total cholesterol and C-reactive protein (CRP) were measured.
The number of leukocytes, neutrophils, monocytes and NLR values in patients with schizophrenia was significantly higher than in the control group. There was no significant relationship between NLR values and the number of hospitalisation, duration of ilness or disease severity in patients. There was no correlation between other laboratory findings and NLR values.
NLR levels are high in schizophrenia independent of metabolic parameters according to the results. So, it can be considered that inflammatory processes may play a role in the etiology of the disease.
免疫和炎症机制在精神分裂症中起重要作用。在文献中，有研究调查中性粒细胞与淋巴细胞比值（NLR）与精神分裂症的关联。
本研究的目的是比较精神分裂症患者与健康对照者的NLR值。此外，该研究旨在调查NLR与疾病严重程度以及一些代谢/炎症参数之间的关系。
本研究纳入了52例诊断为精神分裂症的患者和53名健康对照者。临床医生填写了一份社会人口学信息表。测量了每位患者的身高、体重、腰围和臀围以及血压值。通过阳性和阴性症状量表（PANSS）和临床总体印象-严重程度量表（CGI-S）评估疾病严重程度。对患者组和对照组均进行了全血细胞计数。测量了空腹血糖、胰岛素、糖化血红蛋白（HbA1c）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、甘油三酯、总胆固醇和C反应蛋白（CRP）。
精神分裂症患者的白细胞、中性粒细胞、单核细胞数量和NLR值显著高于对照组。患者的NLR值与住院次数、病程或疾病严重程度之间无显著关系。其他实验室检查结果与NLR值之间无相关性。
根据结果，精神分裂症患者的NLR水平较高，且独立于代谢参数。因此，可以认为炎症过程可能在该疾病的病因中起作用。
