癌症治疗新时代临床试验设计的统计方法
Statistical Methods for Clinical Trial Designs in the New Era of Cancer Treatment.
作者信息
Guo Beibei, Zhang Rui
机构信息
Department of Experimental Statistics, Louisiana State University, USA.
Department of Physics & Astronomy, Louisiana State University, USA.
出版信息
Biostat Biom Open Access J. 2018 Feb;5(3). Epub 2018 Feb 28.
Abstract
Recent success of immunotherapy and other targeted therapies in cancer treatment has signaled the advent of precision medicine. Unlike conventional trial designs that aim to find an optimal treatment ignoring inter-patient heterogeneity, clinical trial designs for precision medicine must take into account patients' variability in genes, environments, and lifestyle. This article provides a review of recent research development of clinical trial designs toward this trend.
摘要
免疫疗法和其他靶向疗法在癌症治疗中的近期成功标志着精准医学的到来。与旨在找到最佳治疗方法而忽略患者间异质性的传统试验设计不同，精准医学的临床试验设计必须考虑患者在基因、环境和生活方式方面的差异。本文综述了针对这一趋势的临床试验设计的最新研究进展。
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