钯催化苄基铵盐通过 C-N 键活化进行酰胺和酯的羰基化反应。
Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters via C-N bond activation.
机构信息
National Research Center for Carbohydrate Synthesis and Key Laboratory of Chemical Biology, Jiangxi Normal University, Nanchang 330022, Jiangxi, P. R. China.
出版信息
Org Biomol Chem. 2018 May 2;16(17):3099-3103. doi: 10.1039/c8ob00488a.
An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C-N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.
首次报道了一种高效的钯催化的季铵盐与 CO 的羰基化反应，通过苄基 C-N 键的断裂，可用于合成芳基乙酰胺和芳基乙酸酯。该反应在常压 CO 条件下，具有温和的反应条件、无需外加氧化剂的氧化还原中性过程以及广泛的底物适用性，可用于各种胺、醇和酚。
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