Fernandes Karin Sá, Gallottini Marina, Castro Talita, Amato Mauricio Flamínio, Lago Juvani Saturno, Braz-Silva Paulo Henrique
Department of Stomatology, University of São Paulo School of Dentistry, São Paulo, Brazil.
Department of Orthodontics and Radiology, University of São Paulo City, UNICID, São Paulo, Brazil.
Spec Care Dentist. 2018 May;38(3):160-162. doi: 10.1111/scd.12283. Epub 2018 Apr 12.
Leukemic infiltration of the gingival tissue associated or not with gingival enlargement may be the first manifestation of acute leukemia, despite being rarely reported in the literature. A 10-year-old female patient presented with a 1-month history of an asymptomatic, firm, and pinkish-red generalized gingival overgrowth. There was no bone resorption. Incisional biopsy of the gingival tissue was performed, with histopathological examination revealing a diffuse and hypercellular infiltration of monocytoid cells. The patient was referred to a hematologist and underwent a bone marrow biopsy, which led to a conclusive diagnosis of acute myeloid leukemia. The patient was treated with chemotherapy and we observed regression of gingival enlargement after 4 weeks from the initial therapy.
牙龈组织的白血病浸润，无论是否伴有牙龈肿大，都可能是急性白血病的首发表现，尽管在文献中鲜有报道。一名10岁女性患者，有1个月无症状、质地坚硬、呈粉红色的广泛性牙龈过度生长病史。无骨质吸收。对牙龈组织进行了切开活检，组织病理学检查显示单核样细胞弥漫性、细胞增多性浸润。该患者被转诊至血液科医生处，并接受了骨髓活检，最终确诊为急性髓系白血病。患者接受了化疗，在初始治疗4周后，我们观察到牙龈肿大消退。
