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Proc Natl Acad Sci U S A. 1988 Mar;85(6):1849-53. doi: 10.1073/pnas.85.6.1849.
2
Antibody against 25,000 dalton tryptic fragment of subfragment-1 from chicken skeletal muscle myosin: functional implication of the 25,000 fragment region in subfragment-1.
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Evidence for bidirectional functional communication between myosin subfragments 1 and 2 in skeletal muscle fibers.骨骼肌纤维中肌球蛋白亚片段1和2之间双向功能通讯的证据。
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本文引用的文献

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The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.用结晶木瓜蛋白酶对兔γ球蛋白和抗体进行水解。
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Proposed mechanism of force generation in striated muscle.横纹肌中力产生的推测机制。
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A mechanochemical mechanism for muscle contraction.肌肉收缩的机械化学机制。
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Movement of myosin fragments in vitro: domains involved in force production.肌球蛋白片段的体外运动：与力产生相关的结构域。
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The sarcomere length-tension relation determined in short segments of intact muscle fibres of the frog.在青蛙完整肌纤维的短节段中测定的肌节长度-张力关系。
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9
Local melting in the subfragment-2 region of myosin in activated muscle and its correlation with contractile force.活化肌肉中肌球蛋白亚片段-2区域的局部熔化及其与收缩力的相关性。
J Mol Biol. 1986 Jul 5;190(1):69-82. doi: 10.1016/0022-2836(86)90076-8.
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肌球蛋白亚片段2抗体对肌纤维收缩力的抑制作用。

Suppression of contractile force in muscle fibers by antibody to myosin subfragment 2.

作者信息

Lovell S, Karr T, Harrington W F

机构信息

Department of Biology, Johns Hopkins University, Baltimore, MD 21218.

出版信息

Proc Natl Acad Sci U S A. 1988 Mar;85(6):1849-53. doi: 10.1073/pnas.85.6.1849.

DOI:10.1073/pnas.85.6.1849
PMID:2964637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC279878/
Abstract

Polyclonal antibody directed against the subfragment-2 region of myosin was purified by affinity chromatography. Skinned muscle fibers that had been preincubated with antibody were able to sustain only 7% of the active isometric force generated by control fibers. The effect of antibody on force production could not be accounted for by inhibition of ATP turnover.

摘要

通过亲和层析法纯化了针对肌球蛋白亚片段-2区域的多克隆抗体。预先用该抗体孵育的去皮肌纤维只能维持对照纤维产生的主动等长力的7%。抗体对力产生的影响不能用ATP周转的抑制来解释。