视盘玻璃膜疣的容积和解剖位置对自发荧光敏感性的影响。

The Influence of Volume and Anatomic Location of Optic Disc Drusen on the Sensitivity of Autofluorescence.

机构信息

Department of Ophthalmology (FCL, LM, SH), Rigshospitalet, University of Copenhagen, Denmark; and Department of Applied Mathematics and Computer Science (A-SWL), Technical University of Denmark, Denmark.

出版信息

J Neuroophthalmol. 2019 Mar;39(1):23-27. doi: 10.1097/WNO.0000000000000654.

DOI:10.1097/WNO.0000000000000654

PMID:29649006

Abstract

BACKGROUND

Optic disc drusen (ODD) are acellular deposits in the optic nerve head. ODD can be diagnosed using different imaging modalities, including enhanced depth imaging optical coherence tomography (EDI-OCT) and autofluorescence (AF). It is unknown which factors determine the sensitivity of AF. The aim of this study was to investigate the effect of volume and anatomic location of ODD on the sensitivity of AF.

METHODS

Cross-sectional study.

RESULTS

A total of 38 patients (75 eyes) with ODD were included. In 12 of 75 eyes (16%) and in 11 of 38 patients (29%), EDI-OCT detected ODD that were not detected by AF. In 24 distinctly solitary ODD, both increase in ODD volume (P = 0.0388) and a more superficial ODD location (P < 0.0001) increased the possibility of AF detection of ODD, when performing a multivariate analysis.

CONCLUSIONS

EDI-OCT is superior to AF in the diagnosis of ODD. Volume and anatomic location of ODD have a significant impact on the sensitivity of AF.

摘要

背景

视盘玻璃膜疣（ODD）是视神经头部的无细胞沉积物。ODD 可以使用不同的成像方式进行诊断，包括增强深度成像光学相干断层扫描（EDI-OCT）和自发荧光（AF）。目前尚不清楚哪些因素决定了 AF 的敏感性。本研究旨在探讨 ODD 的体积和解剖位置对 AF 敏感性的影响。

方法

横断面研究。

结果

共纳入 38 例（75 只眼）ODD 患者。在 75 只眼中的 12 只（16%）和 38 例患者中的 11 只（29%）中，EDI-OCT 检测到了 AF 未检测到的 ODD。在 24 个明显孤立的 ODD 中，当进行多变量分析时，ODD 体积的增加（P = 0.0388）和更浅表的 ODD 位置（P < 0.0001）均增加了 AF 检测 ODD 的可能性。