Rode H N, Puyana J C, Macphee M, Meakins J L, Christou N, Gordon J
Department of Surgery, McGill University, Montreal, Canada.
Clin Exp Immunol. 1988 Jan;71(1):159-63.
Soluble mediators from peripheral blood lymphocytes activated either by skin test antigens or by alloantigens restored the delayed type hypersensitivity (DTH) reaction in the majority of anergic surgical patients who are at increased risk for sepsis and mortality. Antigen had to be injected together with the mediators and the individual had to be reactive to the antigen for restoration. These results suggest that restoration of the DTH response depends on the ability of cytokines produced and acting in a non-specific manner to promote the response of the anergic patients' specific antigen-sensitive cells to antigen.
来自外周血淋巴细胞的可溶性介质，无论是被皮肤试验抗原还是同种异体抗原激活，都能在大多数有败血症和死亡风险增加的无反应性外科患者中恢复迟发型超敏反应（DTH）。抗原必须与介质一起注射，并且个体必须对抗原具有反应性才能实现恢复。这些结果表明，DTH反应的恢复取决于以非特异性方式产生和作用的细胞因子促进无反应性患者的特异性抗原敏感细胞对抗原作出反应的能力。
