Center for Pharmaceutical Biotechnology & Nanomedicine, Department of Pharmaceutical Sciences, Northeastern University, 140 The Fenway, Boston, MA 02115, USA.
Electronic Materials Research Institute, Department of Physics, Northeastern University, 360 Huntington Ave, Boston, MA 02115, USA.
Biomaterials. 2018 Jul;170:26-36. doi: 10.1016/j.biomaterials.2018.03.054. Epub 2018 Mar 31.
Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro. In vivo, the resulting paclitaxel-SPION-co-loaded PEG-PE micelles retained their Magnetic Resonance contrast properties and apoptotic activity in breast and melanoma tumor mouse models. Such theranostic systems are likely to play a significant role in the combined diagnosis and therapy that leads to a more personalized and effective form of treatment.
由于治疗诊断一体化试剂在癌症的同时检测和治疗方面的巨大潜力，人们对其的兴趣持续增长。本研究使用载有疏水性化疗药物紫杉醇和超顺磁性氧化铁纳米颗粒（SPION，一种磁共振成像对比剂）的聚合物聚乙二醇-磷脂酰乙醇胺胶束，制备了一种适用于增强癌症诊断和治疗的基于平台的纳米级组合试剂。共载紫杉醇和 SPION 不会影响彼此的体外功能特性。在体内，载紫杉醇和 SPION 的 PEG-PE 胶束仍保持磁共振对比特性和在乳腺癌及黑色素瘤小鼠模型中的促凋亡活性。这种治疗诊断一体化系统可能在联合诊断和治疗方面发挥重要作用，从而实现更个体化和更有效的治疗方式。
