Kang Min Gyu, Shim Woo Sub, Shin Dong Keun, Kim Joo Yeon, Lee Ji-Eun, Jung Hahn Jin
Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Clin Exp Otorhinolaryngol. 2018 Jun;11(2):81-88. doi: 10.21053/ceo.2018.00031. Epub 2018 Apr 14.
Insertion of a silicone stent during endoscopic dacryocystorhinostomy (DCR) is the most common procedure to prevent rhinostomy closure. It has been claimed that silicone intubation improves the surgical outcomes of endoscopic DCR. However, many reports have documented an equally high success rate for surgery without silicone intubation. Accordingly, we conducted a systematic review and meta-analysis to clarify the outcomes of endoscopic DCR with and without silicone intubation and determine whether silicone intubation is actually beneficial for patients.
PubMed, Embase, and Cochrane Library databases were searched to identify relevant controlled trials evaluating endoscopic DCR with and without silicone intubation. The search was restricted to English articles published between January 2007 and December 2016. Relevant articles were reviewed to obtain information pertaining to interventions and outcomes. We also performed a meta-analysis of the relevant literature.
In total, 1,216 patients included in 12 randomized controlled trials were pooled. A total of 1,239 endoscopic DCR procedures were performed, and silicone stents were used in 533 procedures. The overall success rate for endoscopic DCR was 91.9% (1,139/1,239), while the success rates with and without silicone intubation were 92.9% (495/533) and 91.2% (644/706), respectively. There was no statistically significant heterogeneity among the included studies. A meta-analysis using a fixed-effects models showed no significant difference in the success rate between endoscopic DCR with silicone intubation and that without silicone intubation (OR, 1.38; 95% CI, 0.89 to 2.12; =0.148; z=1.45). Furthermore, there were no significant differences with regard to surgical complications such as synechia, granulation, and postoperative bleeding.
The findings of our meta-analysis suggest that the success rate and postoperative complication rate for endoscopic DCR is not influenced by the use of silicone intubation during the procedure.
在内镜下泪囊鼻腔造口术(DCR)中插入硅胶支架是预防造口闭合最常用的方法。据称,硅胶插管可改善内镜下DCR的手术效果。然而,许多报告记录了无硅胶插管手术的成功率同样很高。因此,我们进行了一项系统评价和荟萃分析,以阐明有无硅胶插管的内镜下DCR的结果,并确定硅胶插管是否真的对患者有益。
检索PubMed、Embase和Cochrane图书馆数据库,以识别评估有无硅胶插管的内镜下DCR的相关对照试验。检索限于2007年1月至2016年12月发表的英文文章。对相关文章进行综述以获取与干预措施和结果相关的信息。我们还对相关文献进行了荟萃分析。
总共纳入了12项随机对照试验中的1216例患者。共进行了1239例内镜下DCR手术,其中533例使用了硅胶支架。内镜下DCR的总体成功率为91.9%(1139/1239),有硅胶插管和无硅胶插管的成功率分别为92.9%(495/533)和91.2%(644/706)。纳入研究之间无统计学显著异质性。使用固定效应模型的荟萃分析显示,有硅胶插管的内镜下DCR与无硅胶插管的内镜下DCR在成功率上无显著差异(比值比,1.38;95%置信区间,0.89至2.×12;P = 0.148;z = 1.45)。此外,在诸如粘连、肉芽组织和术后出血等手术并发症方面也无显著差异。
我们的荟萃分析结果表明,内镜下DCR的成功率和术后并发症发生率不受手术过程中使用硅胶插管的影响。