Ren Weimin, Yang Xiaobo
Center Laboratory, Jinshan Hospital, Fudan University, Shanghai, China.
Department of Neurology, Jinshan Hospital, Fudan University, Shanghai, China.
Front Mol Neurosci. 2018 Mar 29;11:96. doi: 10.3389/fnmol.2018.00096. eCollection 2018.
Stroke is a neurological disease with high disability and fatality rates, and ischemic stroke accounts for 75% of all stroke cases. The underlying pathophysiologic processes of ischemic stroke include oxidative stress, toxicity of excitatory amino acids, excess calcium ions, increased apoptosis and inflammation. Long non-coding RNAs (lncRNAs) may participate in the regulation of the pathophysiologic processes of ischemic stroke as indicated by altered expression of lncRNAs in blood samples of acute ischemic stroke patients, animal models of focal cerebral ischemia and oxygen-glucose deprivation (OGD) cell models. Because of the potentially important role, lncRNAs might be useful as biomarkers for the diagnosis, treatment and prognosis of ischemic stroke. This article reviews the functions of lncRNAs in different pathophysiology events of ischemic stroke with a focus on specific lncRNAs that may underlie ischemic stroke pathophysiology and that could therefore serve as potential diagnostic biomarkers and therapeutic targets.
中风是一种具有高致残率和高死亡率的神经疾病，缺血性中风占所有中风病例的75%。缺血性中风的潜在病理生理过程包括氧化应激、兴奋性氨基酸毒性、钙离子过量、细胞凋亡增加和炎症。急性缺血性中风患者的血液样本、局灶性脑缺血动物模型以及氧糖剥夺（OGD）细胞模型中lncRNAs表达的改变表明，长链非编码RNA（lncRNAs）可能参与缺血性中风病理生理过程的调节。由于其潜在的重要作用，lncRNAs可能作为缺血性中风诊断、治疗和预后的生物标志物。本文综述了lncRNAs在缺血性中风不同病理生理事件中的功能，重点关注可能是缺血性中风病理生理基础、因此可作为潜在诊断生物标志物和治疗靶点的特定lncRNAs。
