Departamento de Zootecnia, Universidade Estadual de Maringá, Maringá, Brazil.
Departamento de Zootecnia, Universidade do Estado de Mato Grosso, Pontes e Lacerda, Brazil.
PLoS One. 2018 Apr 13;13(4):e0195839. doi: 10.1371/journal.pone.0195839. eCollection 2018.
The increasing incidence of diabetes mellitus is becoming a serious threat to human health in various parts of the world. Studies with dairy products have shown a potential beneficial effect against diabetes. This experiment evaluated the supplementation of milk naturally enriched with polyunsaturated fatty acids (PUFA) and polyphenols in rats with streptozotocin-induced diabetes. Forty male 28-day-old Wistar rats were distributed in four experimental treatments of diabetic animals (streptozotocin induction) and a normal group (non-induced). Experimental treatments were: control (water), whole common milk (COM-M), milk enriched with PUFA (PUFA-M), milk enriched with PUFA and polyphenols (PUFA/P-M) through a special diet offered to dairy cows. Milk supplementation at a dose 5 mL/kg body weight was performed for 77 days, 42 days before and 35 days after diabetes induction. The COM-M supplementation increased brown fat deposits, reduced post-induction glucose levels, reduced blood fructosamine levels, and improved glucose tolerance. Milk enriched with PUFA reduced final fasting glucose, LDL levels, and improved blood antioxidant capacity. Milk enriched with PUFA and polyphenols promoted an increase in gastrocnemius muscle mass, and a reduction in mesenteric fat and LDL levels. Milk intake, with an emphasis on milk enriched with PUFA and polyphenols, attenuated the metabolic disorders of streptozotocin-induced diabetes in rats.
糖尿病的发病率不断上升，正在成为世界各地人类健康的严重威胁。乳制品的研究表明其对糖尿病可能具有有益作用。本实验评估了在链脲佐菌素诱导的糖尿病大鼠中补充天然富含多不饱和脂肪酸（PUFA）和多酚的牛奶的效果。将 40 只 28 日龄雄性 Wistar 大鼠分为四组实验性糖尿病动物（链脲佐菌素诱导）和一组正常组（非诱导）。实验处理如下：对照（水）、普通全脂牛奶（COM-M）、富含多不饱和脂肪酸的牛奶（PUFA-M）、通过特殊饮食向奶牛提供富含多不饱和脂肪酸和多酚的牛奶（PUFA/P-M）。在糖尿病诱导前 42 天和诱导后 35 天，以 5 mL/kg 体重的剂量进行牛奶补充。COM-M 补充增加了棕色脂肪沉积，降低了诱导后的血糖水平，降低了血果糖胺水平，并改善了葡萄糖耐量。富含多不饱和脂肪酸的牛奶降低了空腹血糖、LDL 水平，并提高了血液抗氧化能力。富含多不饱和脂肪酸和多酚的牛奶促进了比目鱼肌质量的增加，并降低了肠系膜脂肪和 LDL 水平。强调富含多不饱和脂肪酸和多酚的牛奶摄入可减轻链脲佐菌素诱导的糖尿病大鼠的代谢紊乱。
