Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Clinical Neurophysiology and MEG Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; Department of Neuroscience and Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Neuroscience and Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Neurobiol Aging. 2018 Jul;67:75-83. doi: 10.1016/j.neurobiolaging.2018.03.013. Epub 2018 Mar 19.
We studied neurophysiological indicators of hallucinations in Alzheimer's disease patients with hallucinations (ADhall+), and compared them with nonhallucinating AD (ADhall-) and dementia with Lewy bodies (DLBhall+) patients. Thirty-six matched ADhall+ and 108 ADhall- and 29 DLBhall+ patients were selected from the Amsterdam Dementia Cohort. Electroencephalography (EEG) spectral and functional connectivity (FC) analyses (phase lag index) were performed. Quantitative and visual EEG measures were combined in a random forest algorithm to determine which EEG-based variable(s) play a role in hallucinations. ADhall+ patients showed lower peak frequency (7.26 vs. 7.94 Hz, p < 0.01), α2-and β-power, and α2-FC but higher δ-power compared to ADhall-. ADhall+ showed lower δ-power, higher β-power, and α1-FC than DLBhall+ but did not differ in peak frequency (7.26 vs. 6.95 Hz), θ- or α-power. ADhall+ patients could be differentiated from ADhall- and DLBhall+ with a weighted accuracy of 71% with α1-power and 100% with β-FC, the 2 most differentiating features. In sum, EEG slowing and decrease in α1-and β-band activity form potential neurophysiological indicators of underlying cholinergic deficiency in ADhall+ and DLBhall+.
我们研究了有幻觉的阿尔茨海默病患者（ADhall+）的神经生理幻觉指标，并将其与无幻觉的阿尔茨海默病患者（ADhall-）和路易体痴呆患者（DLBhall+）进行了比较。从阿姆斯特丹痴呆队列中选择了 36 名匹配的 A Dhall+和 108 名 A Dhall-和 29 名 D L Bhall+患者。进行了脑电图（EEG）频谱和功能连接（相位滞后指数）分析。将定量和视觉脑电图测量值结合在随机森林算法中，以确定哪些基于 EEG 的变量在幻觉中起作用。与 A Dhall-相比，A Dhall+患者的峰值频率（7.26 对 7.94 Hz，p < 0.01）、α2 和β功率以及α2-FC 较低，而δ功率较高。与 D L Bhall+相比，A Dhall+患者的δ功率较低，β功率较高，α1-FC 较高，但峰值频率（7.26 对 6.95 Hz）、θ或α功率无差异。A Dhall+患者可通过α1 功率的加权准确率为 71%和β-FC 的 100%与 A Dhall-和 D L Bhall+区分。总之，EEG 减慢和α1-和β波段活动减少可能是 A Dhall+和 D L Bhall+中潜在胆碱能缺乏的神经生理指标。
