Kammerer Adrian, Staab Holger, Herberg Maria, Kerner Christine, Klöting Nora, Aust Gabriela
Research Laboratories; Clinic for Visceral, Transplantation, Thoracic and Vascular Surgery, Leipzig University, Liebigstr. 19, D-04103, Leipzig, Germany.
Clinic for Visceral, Transplantation, Thoracic and Vascular Surgery, University Medical Centre Leipzig, Leipzig, Germany.
BMC Cardiovasc Disord. 2018 Apr 13;18(1):65. doi: 10.1186/s12872-018-0803-7.
Chemerin is an adipokine which plays a crucial role in atherosclerosis. Here, we examined whether circulating chemerin is enhanced in patients with advanced carotid stenosis.
Chemerin was quantified in 178 patients prior to carotid end arterectomy (CEA) and in age- and gender-matched controls (n = 163). Chemerin levels were related to anthropometric, clinical and metabolic characteristics of the patients.
Chemerin levels were higher in patients compared to controls (p < 0.001). Chemerin correlated to parameters associated with inflammation such as C-reactive protein (CRP, p < 0.001), leukocyte blood count (p < 0.001) and circulating TNF-α (p = 0.004) in the patients. Chemerin levels did not differ between asymptomatic (n = 93) and symptomatic patients who experienced an ischemic event within 6 months prior to CEA (n = 85). However, in the case of high-grade carotid stenosis (≥ 90%), chemerin levels were higher in symptomatic (n = 44) compared to asymptomatic patients (n = 41, p = 0.014). Chemerin was increased in patients with (n = 50) compared to patients without (n = 128) coronary artery disease (CAD, p = 0.002). A high level of chemerin increases the risk for CAD in patients (p = 0.0013).
Circulating chemerin is increased and correlates to inflammatory parameters in patients with advanced carotid stenosis.
chemerin是一种脂肪因子，在动脉粥样硬化中起关键作用。在此，我们研究了晚期颈动脉狭窄患者循环中的chemerin是否升高。
对178例行颈动脉内膜切除术（CEA）的患者及年龄和性别匹配的对照组（n = 163）进行chemerin定量检测。chemerin水平与患者的人体测量学、临床和代谢特征相关。
患者的chemerin水平高于对照组（p < 0.001）。患者的chemerin与炎症相关参数如C反应蛋白（CRP，p < 0.001）、白细胞计数（p < 0.001）和循环肿瘤坏死因子-α（p = 0.004）相关。无症状患者（n = 93）与在CEA前6个月内发生缺血事件的有症状患者（n = 85）之间的chemerin水平无差异。然而，在重度颈动脉狭窄（≥90%）的情况下，有症状患者（n = 44）的chemerin水平高于无症状患者（n = 41，p = 0.014）。与无冠状动脉疾病（CAD，n = 128）的患者相比，有CAD的患者（n = 50）chemerin升高（p = 0.002）。高水平的chemerin增加了患者患CAD的风险（p = 0.0013）。
晚期颈动脉狭窄患者循环中的chemerin升高，且与炎症参数相关。
