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输尿管原发性肉瘤样尿路上皮癌:病例报告及文献复习。

Primary sarcomatoid urothelial carcinoma of the ureter: a case report and review of the literature.

机构信息

Department of Urology, The Fourth Hospital Affiliated to China Medical University, Chongshan East street, Shenyang, Liaoning, 110032, People's Republic of China.

出版信息

World J Surg Oncol. 2018 Apr 13;16(1):77. doi: 10.1186/s12957-018-1383-9.

Abstract

BACKGROUND

Sarcomatoid urothelial carcinoma is a very dangerous malignant tumour derived from the epithelium. Primary sarcomatoid carcinoma of the ureter is extremely rare in clinical practice. The prognosis of this kind of disease is really poor, and there is still not a diagnosis standard in the world.

CASE PRESENTATION

An 82-year-old female patient who had intermittent waist pain without any other symptoms, had diagnosed as urothelial cancer on computerised tomography urography. Considering the patient's age and quality of life, we made a preserving kidneys resection of the local tumour. The tumour was composed of sarcomatous and carcinomatous elements, and immunohistochemical examination showed that tumour cells were positive for cytokeratin, epithelial membrane antigen, vimentin, and GATA3 markers. There were no complications after 1-hour surgery. After 3 months, there was no signs of recurrence and metastasis.

CONCLUSION

This case was a patient with sacomatoid urothelial carcinoma. Through a transurethral resection with laser, the patient recovered well, and there was no sign of any recurrence of the tumour after 3 months. With the development of technology and science, more and more cancerous patients' living quality and survival rate were improved. Maybe it is essential for urologists and scientists to entirely understand the characteristics of the sarcomatoid urothelial carcinoma and make a better clinical guideline.

摘要

背景

梭形细胞尿路上皮癌是一种非常危险的恶性肿瘤,来源于上皮组织。原发性输尿管梭形细胞癌在临床上极为罕见。这种疾病的预后确实很差,目前世界上还没有一个诊断标准。

病例介绍

一位 82 岁的女性患者,间歇性腰痛,无其他任何症状,在计算机断层尿路造影检查中被诊断为尿路上皮癌。考虑到患者的年龄和生活质量,我们对局部肿瘤进行了保肾局部肿瘤切除术。肿瘤由肉瘤样和癌性成分组成,免疫组织化学检查显示肿瘤细胞对细胞角蛋白、上皮膜抗原、波形蛋白和 GATA3 标志物呈阳性。术后 1 小时无并发症。3 个月后,无复发和转移迹象。

结论

本例为梭形细胞尿路上皮癌患者。通过经尿道切除加激光治疗,患者恢复良好,3 个月后未见肿瘤复发迹象。随着技术和科学的发展,越来越多的癌症患者的生活质量和生存率得到了提高。也许对于泌尿科医生和科学家来说,全面了解梭形细胞尿路上皮癌的特征并制定更好的临床指南至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c76/5899376/7d4d3403e923/12957_2018_1383_Fig1_HTML.jpg

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