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发生于女性尿道憩室的肉瘤样尿路上皮癌。

Sarcomatoid urothelial carcinoma arising in the female urethral diverticulum.

作者信息

Park Heae Surng

机构信息

Department of Pathology, Ewha Womans University Seoul Hospital, Seoul, Korea.

出版信息

J Pathol Transl Med. 2021 Jul;55(4):298-302. doi: 10.4132/jptm.2021.04.23. Epub 2021 Jun 1.

DOI:10.4132/jptm.2021.04.23
PMID:34058799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8353136/
Abstract

A sarcomatoid variant of urothelial carcinoma in the female urethral diverticulum has not been reported previously. A 66-year-old woman suffering from dysuria presented with a huge urethral mass invading the urinary bladder and vagina. Histopathological examination of the resected specimen revealed predominantly undifferentiated pleomorphic sarcoma with sclerosis. Only a small portion of conventional urothelial carcinoma was identified around the urethral diverticulum, which contained glandular epithelium and villous adenoma. The patient showed rapid systemic recurrence and resistance to immune checkpoint inhibitor therapy despite high expression of programmed cell death ligand-1. We report the first case of urethral diverticular carcinoma with sarcomatoid features.

摘要

女性尿道憩室尿路上皮癌的肉瘤样变体此前尚未见报道。一名66岁患有排尿困难的女性出现巨大尿道肿物，侵犯膀胱和阴道。切除标本的组织病理学检查显示主要为伴有硬化的未分化多形性肉瘤。仅在尿道憩室周围发现一小部分传统尿路上皮癌，其中包含腺上皮和绒毛状腺瘤。尽管程序性细胞死亡配体-1高表达，但该患者仍出现快速的全身复发且对免疫检查点抑制剂治疗耐药。我们报告首例具有肉瘤样特征的尿道憩室癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d43/8353136/7a3c91b11359/jptm-2021-04-23f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d43/8353136/5f9bc2ade37a/jptm-2021-04-23f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d43/8353136/e78f979ef43e/jptm-2021-04-23f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d43/8353136/7a3c91b11359/jptm-2021-04-23f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d43/8353136/5f9bc2ade37a/jptm-2021-04-23f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d43/8353136/e78f979ef43e/jptm-2021-04-23f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d43/8353136/7a3c91b11359/jptm-2021-04-23f3.jpg

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本文引用的文献

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Sarcomatoid variant urothelial carcinoma of the bladder: a systematic review and meta-analysis of the clinicopathological features and survival outcomes.膀胱肉瘤样变型尿路上皮癌：临床病理特征及生存结局的系统评价和荟萃分析
Cancer Cell Int. 2020 Nov 14;20(1):550. doi: 10.1186/s12935-020-01626-9.
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Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes.评估按组织学变体和分子亚型分层的膀胱尿路上皮癌中的 PD-L1 和其他免疫标志物。
Sci Rep. 2020 Jan 29;10(1):1439. doi: 10.1038/s41598-020-58351-6.
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Urethral diverticulum carcinoma in females-a case series and review of the English and Japanese literature.
女性尿道憩室癌——病例系列及英文和日文文献综述
Transl Androl Urol. 2018 Aug;7(4):703-729. doi: 10.21037/tau.2018.07.08.
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Primary sarcomatoid urothelial carcinoma of the ureter: a case report and review of the literature.输尿管原发性肉瘤样尿路上皮癌：病例报告及文献复习。
World J Surg Oncol. 2018 Apr 13;16(1):77. doi: 10.1186/s12957-018-1383-9.
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Sarcomatoid Variant of Urothelial Carcinoma of the Renal Pelvis with Inferior Vena Cava Tumour Thrombus: A Case Report and Literature Review.肾盂尿路上皮癌伴下腔静脉肿瘤血栓形成的肉瘤样变体：一例报告及文献复习
Case Rep Pathol. 2018 Jan 17;2018:1837510. doi: 10.1155/2018/1837510. eCollection 2018.
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