Huffington Center on Aging, Stem Cells and Regenerative Medicine Center, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, United States.
Prog Mol Biol Transl Sci. 2018;155:85-107. doi: 10.1016/bs.pmbts.2017.12.003. Epub 2018 Feb 1.
Metabolic changes are hallmarks of aging and genetic and pharmacologic alterations of relevant pathways can extend life span. In this review, we will outline how cellular biochemistry and energy homeostasis change during aging. We will highlight protein quality control, mitochondria, epigenetics, nutrient-sensing pathways, as well as the interplay between these systems with respect to their impact on cellular health.
代谢变化是衰老的标志，相关途径的遗传和药物改变可以延长寿命。在这篇综述中，我们将概述细胞生物化学和能量平衡如何在衰老过程中发生变化。我们将重点介绍蛋白质质量控制、线粒体、表观遗传学、营养感应途径，以及这些系统之间的相互作用，以及它们对细胞健康的影响。
