Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Northwestern University, Chicago, IL, USA.
Arch Womens Ment Health. 2019 Feb;22(1):129-132. doi: 10.1007/s00737-018-0841-2. Epub 2018 Apr 13.
CRP has been positively correlated with depressive symptomatology but this has received less study in postpartum depression (PPD). In this secondary analysis of a trial of PPD treatment, depressive symptoms (Structured Interview Guide for the Hamilton Depression Rating Scale-Atypical Depression Symptoms (SIGH-ADS)) and serum CRP levels were assessed and associations between CRP and SIGH-ADS scores evaluated. The associations between baseline log CRP and depression response and remission were also assessed. Of the 35 women included, neither baseline log CRP nor exit log CRP was significantly associated with SIGH-ADS score. Baseline CRP was not associated with response or remission. In this sample of women with PPD, CRP was not associated with depressive symptoms nor response to treatment.
C 反应蛋白（CRP）与抑郁症状呈正相关，但这在产后抑郁症（PPD）中研究较少。在 PPD 治疗试验的二次分析中，评估了抑郁症状（汉密尔顿抑郁评定量表-非典型抑郁症状的结构访谈指南（SIGH-ADS））和血清 CRP 水平，并评估了 CRP 与 SIGH-ADS 评分之间的关联。还评估了基线 CRP 对数与抑郁反应和缓解之间的关联。在纳入的 35 名女性中，基线 CRP 对数和退出 CRP 对数均与 SIGH-ADS 评分无显著相关性。基线 CRP 与反应或缓解无关。在本 PPD 女性样本中，CRP 与抑郁症状以及对治疗的反应无关。
