Pendeloski Karen Priscilla Tezotto, Ono Erika, Torloni Maria Regina, Mattar Rosiane, Daher Silvia
Department of Obstetrics, Universidade Federal de São Paulo, São Paulo, Sao Paulo, Brazil.
Am J Reprod Immunol. 2017 May;77(5). doi: 10.1111/aji.12674. Epub 2017 Mar 22.
The link between maternal obesity and inflammatory mediators is still unclear. Our aim was to summarize the main findings of recently published studies on this topic. We performed a search in Medline for studies published in the last years on obesity, human pregnancy, and inflammatory mediators. We report the findings of 30 studies. The characteristics and number of participants, study design, gestational age at sample collection, and type of sample varied widely. Approximately two-thirds of them investigated more than one mediator, and 50% included participants in only one trimester of pregnancy. The most frequently investigated mediators were leptin, tumour necrosis factor-alpha (TNF-α), and interleukin (IL)-6. Almost all studies reported an association between maternal obesity, leptin, and C-reactive protein (CRP) serum levels but not with IL-1β and IL-10. The association of IL-6, TNF-α, monocyte chemo-attractant protein-1 (MCP-1), adiponectin, and resistin with maternal obesity is still controversial. To clarify the physiopathological link between maternal obesity and inflammation, more high-quality studies are needed.
母体肥胖与炎症介质之间的联系仍不清楚。我们的目的是总结最近发表的关于该主题研究的主要发现。我们在Medline中搜索了过去几年发表的关于肥胖、人类妊娠和炎症介质的研究。我们报告了30项研究的结果。参与者的特征和数量、研究设计、样本采集时的孕周以及样本类型差异很大。其中约三分之二的研究调查了不止一种介质，50%的研究仅纳入了孕期一个阶段的参与者。研究最频繁的介质是瘦素、肿瘤坏死因子-α（TNF-α）和白细胞介素（IL）-6。几乎所有研究都报告母体肥胖、瘦素和血清C反应蛋白（CRP）水平之间存在关联，但与IL-1β和IL-10无关。IL-6、TNF-α、单核细胞趋化蛋白-1（MCP-1）、脂联素和抵抗素与母体肥胖之间的关联仍存在争议。为了阐明母体肥胖与炎症之间的生理病理联系，需要更多高质量的研究。
