Sánchez-Vásquez Estefanía, Alata Jimenez Nagif, Vázquez Nicolás A, Strobl-Mazzulla Pablo H
Laboratory of Developmental Biology, Instituto de Investigaciones Biotecnológicas- Instituto Tecnológico de Chascomús (CONICET-UNSAM), Int. Marino 8200, Chascomús 7130, Argentina.
Laboratory of Developmental Biology, Instituto de Investigaciones Biotecnológicas- Instituto Tecnológico de Chascomús (CONICET-UNSAM), Int. Marino 8200, Chascomús 7130, Argentina.
Mech Dev. 2018 Dec;154:24-32. doi: 10.1016/j.mod.2018.04.002. Epub 2018 Apr 11.
The central dogma of molecular biology statically says that the information flows from DNA to messenger RNA to protein. But the recent advances in mass spectrometry and high throughput technology have helped the scientists to view RNA as little more than a courier of genetic information encoded in the DNA. The dynamics of RNA modifications in coding and non-coding RNAs are just emerging as a carrier of non-genetic information, uncovering a new layer of complexity in the regulation of gene expression and protein translation. In this review, we summarize about the current knowledge of N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C) and pseudouridine (Ψ) modifications in RNA, and described how these RNA modifications are implicated in early animal development and in several human diseases.
分子生物学的中心法则静态地表明，信息从DNA流向信使RNA再流向蛋白质。但质谱和高通量技术的最新进展帮助科学家认识到，RNA不仅仅是DNA中编码的遗传信息的传递者。编码RNA和非编码RNA中RNA修饰的动态变化刚刚作为非遗传信息的载体出现，揭示了基因表达和蛋白质翻译调控中一个新的复杂层面。在这篇综述中，我们总结了目前关于RNA中N6-甲基腺苷（m6A）、N1-甲基腺苷（m1A）、5-甲基胞嘧啶（m5C）和假尿苷（Ψ）修饰的知识，并描述了这些RNA修饰如何与动物早期发育和几种人类疾病相关。
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