住宅氡气与小细胞肺癌。系统综述。
Residential radon and small cell lung cancer. A systematic review.
机构信息
Service of Medical Oncology, University Hospital Complex of Pontevedra, Spain; Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain.
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain; Service of Neumology, University Hospital Complex of Vigo, Spain.
出版信息
Cancer Lett. 2018 Jul 10;426:57-62. doi: 10.1016/j.canlet.2018.04.003. Epub 2018 Apr 11.
Residential radon exposure is considered the second cause of lung cancer and the first in never smokers. Nevertheless, the association between the different histological types of lung cancer and radon is not completely clear, and radon effect on small cell lung cancer is not completely understood. We aim to asses the effect of residential radon exposure on the risk of small cell lung cancer (SCLC) in general population and miners through a systematic review applying predefined inclusion and exclusion criteria. 16 studies were included. Most of them point to a relationship between indoor radon and SCLC, though some investigations show no association. When comparing the risk of SCLC due to radon exposure with NSCLC, it can be observed that an increased risk for SCLC is present. Small cell lung cancer seems to be the histological type of lung cancer most tightly related with residential radon.
住宅内氡暴露被认为是肺癌的第二大病因，也是从不吸烟者肺癌的首要病因。然而，不同组织学类型的肺癌与氡之间的关系尚不完全清楚，氡对小细胞肺癌的影响也不完全清楚。我们旨在通过系统评价应用预先确定的纳入和排除标准，评估住宅内氡暴露对一般人群和矿工患小细胞肺癌（SCLC）的风险的影响。共纳入了 16 项研究。大多数研究表明室内氡与 SCLC 之间存在关系，但也有一些研究表明没有关联。当比较由于氡暴露导致的 SCLC 与 NSCLC 的风险时，可以观察到 SCLC 的风险增加。小细胞肺癌似乎是与住宅内氡暴露关系最密切的肺癌组织学类型。
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