Service of Medical Oncology, Santiago de Compostela University Hospital, Santiago de Compostela, Spain.
Departamento de Medicina Preventiva y Salud Pública, Universidad de Medicina, Universidad de Santiago de Compostela, C/ San Francisco s/n., 15782, Santiago de Compostela, Spain.
Sci Rep. 2023 Mar 23;13(1):4727. doi: 10.1038/s41598-023-31991-0.
Small cell lung cancer (SCLC) comprises approximately 10% of all lung cancer cases. Tobacco is its main risk factor; however, occupation might play a role in this specific lung cancer subtype. The effect of occupation on SCLC risk has been hardly studied and therefore we aim to assess the role of occupation on the risk of SCLC. To do this, we designed a multicentric, hospital-based, case-control study. Cases consisted exclusively in SCLC patients and controls were recruited from patients having minor surgery at the participating hospitals. Face to face interviews emphasizing occupation and tobacco consumption were held and residential radon was also measured. Logistic regression models were adjusted with odds ratios with 95%CI as estimations of the effect. 423 cases and 905 controls were included. Smoking prevalence was higher in cases compared to controls. Those who worked in known-risk occupations for lung cancer showed an OR of 2.17 (95%CI 1.33; 3.52), with a similar risk when men were analysed separately. The results were adjusted by age, sex, smoking and indoor radon exposure. Those who worked in known-risk occupations and were moderate or heavy smokers had a SCLC risk of 12.19 (95%CI 5.68-26.38) compared with never or moderate smokers who had not worked in such occupations. Occupation is a relevant risk factor of SCLC, and it seems that its effect is boosted when tobacco smoking is present.
小细胞肺癌（SCLC）约占所有肺癌病例的 10%。烟草是其主要危险因素；然而，职业可能在这种特定的肺癌亚型中发挥作用。职业对 SCLC 风险的影响几乎没有研究过，因此我们旨在评估职业对 SCLC 风险的作用。为此，我们设计了一项多中心、基于医院的病例对照研究。病例仅由 SCLC 患者组成，对照组由在参与医院接受小手术的患者招募。进行了面对面访谈，强调职业和吸烟情况，并测量了住宅氡气。使用优势比（OR）及其 95%置信区间（CI）作为效应的估计值，调整了逻辑回归模型。共纳入 423 例病例和 905 例对照。病例组的吸烟率高于对照组。那些从事已知肺癌风险职业的人，其 OR 为 2.17（95%CI 1.33；3.52），当单独分析男性时，风险相似。结果通过年龄、性别、吸烟和室内氡暴露进行了调整。与从未或适度吸烟且未从事此类职业的人相比，从事已知风险职业且为重度或重度吸烟者的 SCLC 风险为 12.19（95%CI 5.68-26.38）。职业是 SCLC 的一个重要危险因素，而且似乎在吸烟存在的情况下，其影响会增强。
