Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Structural Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China.
Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Beijing Advanced Innovation Center for Structural Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China.
Curr Opin Chem Biol. 2018 Oct;46:33-40. doi: 10.1016/j.cbpa.2018.03.018. Epub 2018 Apr 11.
Native chemical ligation (NCL) has become one of the most important methods in chemical syntheses of proteins. Recently, in order to expand its scope, considerable effort has been devoted to tuning the C-terminal acyl donor thioesters used in NCL. This article reviews the recent advances in the design of C-terminal acyl donors, their precursors and surrogates, and highlights some noteworthy progress that may lead the future direction of protein chemical synthesis.
天然化学连接（NCL）已成为蛋白质化学合成中最重要的方法之一。最近，为了扩大其应用范围，人们在很大程度上致力于调整 NCL 中使用的 C 末端酰基供体硫酯。本文综述了 C 末端酰基供体、其前体和替代物的设计的最新进展，并重点介绍了一些可能引领蛋白质化学合成未来方向的显著进展。
