Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, Ocean University of China, Qingdao 266003, China.
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China.
Food Chem. 2018 Aug 30;258:231-236. doi: 10.1016/j.foodchem.2018.03.076. Epub 2018 Mar 19.
Glycans in human milk serve several important biological functions that promote infant health. As kind of important glycans, glycosaminoglycans (GAGs) are a complex family of polyanionic carbohydrate, participating in a variety of critical physiological and pathological processes. In this study, the content and the detailed composition of human milk GAGs from Chinese mothers in different stages of lactation, based on a liquid chromatography-tandem mass spectrometry approach was investigated. The results showed that the GAG fraction in the human milk samples was very complex as it was composed of heparan sulfate, chondroitin sulfate, and hyaluronic acid. With lactation extending, the total amount of GAGs in human milk decreased. This study provided an important guide for the demands of GAGs during different stages of lactation. The results were also beneficial for studies on the composition and functional properties of infant formula.
人乳中的聚糖具有多种促进婴儿健康的重要生物学功能。糖胺聚糖 (GAGs) 作为一种重要的聚糖，是一类复杂的聚阴离子碳水化合物，参与多种关键的生理和病理过程。在这项研究中，基于液相色谱-串联质谱法，研究了不同哺乳期中国母亲人乳 GAG 的含量和详细组成。结果表明，人乳样品中的 GAG 部分非常复杂，由肝素硫酸盐、软骨素硫酸盐和透明质酸组成。随着哺乳期的延长，人乳中 GAG 的总量减少。这项研究为人乳中 GAG 在不同哺乳期的需求提供了重要指导。这些结果也有利于婴儿配方组成和功能特性的研究。
