Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Gene. 2018 Jul 15;663:34-40. doi: 10.1016/j.gene.2018.04.030. Epub 2018 Apr 12.
Several studies have reported the role of hedgehog interacting protein-like 1 (HHIPL-1) in different pathologies, including cardiovascular disease. The aim of the present study was to analyze the association of HHIPL-1 (rs2895811) polymorphism with myocardial infarction (MI), cardiometabolic parameters, and traditional cardiovascular risk factors in the Mexican population. The polymorphism was genotyped using a TaqMan assay in 1023 patients with MI and 1105 controls. A similar distribution of the polymorphism was observed between studied groups. However, in patients group, the C allele was associated with a decreased risk of developing hypertriglyceridemia (OR = 0.757, P = 0.030, OR = 0.685, P = 0.020, OR = 0.691, P = 0.030), metabolic syndrome (OR = 0.746, P = 0.030, OR = 0.647, P = 0.005, OR = 0.670, P = 0.015, OR = 0.637, P = 0.005), and insulin resistance (OR = 0.681, P = 0.045). The results suggest that HHIPL-1 rs2895811 polymorphism is associated with cardiometabolic parameters in Mexican patients with MI.
几项研究报告了 hedgehog 相互作用蛋白样 1（HHIPL-1）在包括心血管疾病在内的不同病理中的作用。本研究旨在分析 HHIPL-1（rs2895811）多态性与墨西哥人群中心肌梗死（MI）、心脏代谢参数和传统心血管危险因素的关系。该多态性使用 TaqMan 测定法在 1023 名 MI 患者和 1105 名对照中进行了基因分型。在研究组之间观察到该多态性的分布相似。然而，在患者组中，C 等位基因与发生高甘油三酯血症（OR=0.757，P=0.030，OR=0.685，P=0.020，OR=0.691，P=0.030）、代谢综合征（OR=0.746，P=0.030，OR=0.647，P=0.005，OR=0.670，P=0.015，OR=0.637，P=0.005）和胰岛素抵抗（OR=0.681，P=0.045）的风险降低相关。结果表明，HHIPL-1 rs2895811 多态性与墨西哥 MI 患者的心脏代谢参数相关。
