Uysal Nazan, Yuksel Oguz, Kizildag Servet, Yuce Zeynep, Gumus Hikmet, Karakilic Aslı, Guvendi Guven, Koc Basar, Kandis Sevim, Ates Mehmet
Department of Physiology, Dokuz Eylul University, School of Medicine, Izmir, Turkey.
Department of Sports Medicine, Dokuz Eylul University, School of Medicine, Izmir, Turkey.
Neurosci Lett. 2018 May 29;676:92-97. doi: 10.1016/j.neulet.2018.04.023. Epub 2018 Apr 12.
We have recently shown that regular voluntary aerobic exercised rats have low levels of anxiety. Irisin is an exercise-induced myokine that is produced by many tissues; and the role it plays in anxiolytic behavior is unknown. In this study we aimed to investigate the correlation between anxiety like behavior and irisin levels following regular voluntary aerobic exercise in male mice. We've have shown that anxiety levels decreased in exercised mice, while irisin levels increased in the brain, brown adipose tissue, white adipose tissue, kidney, and pancreas tissues. No significant difference of irisin levels in the liver, muscle and serum were detected in the exercise group, when compared to controls. In addition, there was a strong positive correlation between brain irisin levels and activity in middle area of open field test and in the open arms of elevated plus maze test; both which are indicators of low anxiety levels. Our results suggest that decrease in anxiolytic behavior due to regular voluntary exercise may be associated with locally produced brain irisin. White adipose tissue irisin levels also correlated very strongly with low anxiety. However, no serum irisin increase was detected, ruling out the possibility of increased peripheral irisin levels affecting the brain via the bloodstream. Further research is necessary to explain the mechanisms of which peripheral and central irisin effects anxiety and the brain region affected.
我们最近发现，定期进行自愿有氧运动的大鼠焦虑水平较低。鸢尾素是一种运动诱导的肌动蛋白，由许多组织产生；其在抗焦虑行为中所起的作用尚不清楚。在本研究中，我们旨在调查雄性小鼠定期进行自愿有氧运动后，焦虑样行为与鸢尾素水平之间的相关性。我们已经表明，运动小鼠的焦虑水平降低，而大脑、棕色脂肪组织、白色脂肪组织、肾脏和胰腺组织中的鸢尾素水平升高。与对照组相比，运动组的肝脏、肌肉和血清中的鸢尾素水平没有显著差异。此外，大脑鸢尾素水平与旷场试验中区活动以及高架十字迷宫试验开放臂活动之间存在很强的正相关；这两者都是低焦虑水平的指标。我们的结果表明，定期自愿运动导致的抗焦虑行为减少可能与大脑局部产生的鸢尾素有关。白色脂肪组织鸢尾素水平也与低焦虑密切相关。然而，未检测到血清鸢尾素增加，排除了外周鸢尾素水平升高通过血流影响大脑的可能性。有必要进行进一步研究，以解释外周和中枢鸢尾素影响焦虑的机制以及受影响的脑区。
