Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan.
Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan.
Int J Cardiol. 2018 Jun 15;261:12-17. doi: 10.1016/j.ijcard.2017.11.072.
Irisin, a recently identified myokine, regulates mitochondrial function and energy expenditure. The concentration of irisin is significantly altered after ST-elevation myocardial infarction (STEMI). We hypothesized that serum irisin concentration is associated with adverse cardiovascular outcomes after myocardial infarction. Serum irisin concentrations were measured using enzyme-linked immunosorbent assay (ELISA) in 399 patients 28d after the onset of STEMI in a prospective single-center cohort study. We assessed the association between irisin concentrations and adverse cardiovascular events during a 3-year follow-up. The excess risks of cardiovascular mortality, stroke, heart failure, and revascularization were predominantly seen among those with the highest concentrations of irisin, with concentrations higher than 75th percentile of the overall distribution had a ~4-fold increase in risk (hazard ratio=3.96, 95% confidence interval 1.55 to 10.11, P<0.01). Our findings showed that serum concentrations of irisin are elevated in post-STEMI patients with increased risk for adverse cardiovascular events. Novel therapies targeting irisin may represent a new direction in the treatment of STEMI.
鸢尾素是一种新发现的肌肉因子，可调节线粒体功能和能量消耗。在 ST 段抬高型心肌梗死（STEMI）后，鸢尾素的浓度会发生明显改变。我们假设血清鸢尾素浓度与心肌梗死后的不良心血管结局有关。在一项前瞻性单中心队列研究中，我们使用酶联免疫吸附试验（ELISA）检测了 399 例 STEMI 发病 28 天后患者的血清鸢尾素浓度，并评估了其与 3 年随访期间不良心血管事件之间的相关性。在最高浓度的鸢尾素患者中，心血管死亡率、卒中和心力衰竭以及血运重建的额外风险主要增加，高于整体分布第 75 百分位数的浓度，其风险增加约 4 倍（风险比=3.96，95%置信区间 1.55 至 10.11，P<0.01）。我们的研究结果表明，STEMI 后患者的血清鸢尾素浓度升高，发生不良心血管事件的风险增加。针对鸢尾素的新型治疗方法可能代表 STEMI 治疗的新方向。
