FNDC5/鸢尾素在心血管疾病中的作用。
The Role of FNDC5/Irisin in Cardiovascular Disease.
机构信息
Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Department of Human Biology, Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland.
出版信息
Cells. 2024 Feb 2;13(3):277. doi: 10.3390/cells13030277.
Disorders of cardiomyocyte metabolism play a crucial role in many cardiovascular diseases, such as myocardial infarction, heart failure and ischemia-reperfusion injury. In myocardial infarction, cardiomyocyte metabolism is regulated by mitochondrial changes and biogenesis, which allows energy homeostasis. There are many proteins in cells that regulate and control metabolic processes. One of them is irisin (Ir), which is released from the transmembrane protein FNDC5. Initial studies indicated that Ir is a myokine secreted mainly by skeletal muscles. Further studies showed that Ir was also present in various tissues. However, its highest levels were observed in cardiomyocytes. Ir is responsible for many processes, including the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT) by increasing the expression of thermogenin (UCP1). In addition, Ir affects mitochondrial biogenesis. Therefore, the levels of FNDC5/Ir in the blood and myocardium may be important in cardiovascular disease. This review discusses the current knowledge about the role of FNDC5/Ir in cardiovascular disease.
心肌细胞代谢紊乱在许多心血管疾病中起着关键作用，如心肌梗死、心力衰竭和缺血再灌注损伤。在心肌梗死中，心肌细胞代谢受线粒体变化和生物发生的调节，以维持能量平衡。细胞中有许多蛋白质调节和控制代谢过程。其中之一是鸢尾素（Ir），它由跨膜蛋白 FNDC5 释放。最初的研究表明，Ir 是一种主要由骨骼肌分泌的肌因子。进一步的研究表明，Ir 也存在于各种组织中。然而，其含量最高的组织是心肌细胞。Ir 负责许多过程，包括通过增加解偶联蛋白 1（UCP1）的表达将白色脂肪组织（WAT）转化为棕色脂肪组织（BAT）。此外，Ir 还影响线粒体生物发生。因此，血液和心肌中 FNDC5/Ir 的水平在心血管疾病中可能很重要。本文综述了目前关于 FNDC5/Ir 在心血管疾病中的作用的知识。
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