Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Institute of Pathology, Martin Luther University Halle-Wittenberg, 06112 Halle, Germany.
Department of Obstetrics and Gynecology, Johns Hopkins Hospital, Baltimore, MD 21287-1281, USA.
Cancer Cell. 2018 Jun 11;33(6):965-983. doi: 10.1016/j.ccell.2018.03.002. Epub 2018 Apr 12.
Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment.
除了在限制出血和促进伤口愈合方面的作用外，实验证据还强调了血小板在肿瘤发生的所有步骤中都是活跃的参与者，包括肿瘤生长、肿瘤细胞渗出和转移。此外，癌症患者的血小板增多与患者不良预后相关。由于大量分泌微粒和外泌体，血小板非常适合协调局部和远处肿瘤-宿主的串扰。在这里，我们回顾了血小板生物学领域的最新发现以及血小板在癌症进展中的作用，以及针对癌症治疗靶向血小板所面临的挑战。
