我们是否正通过饮食走向前列腺癌——基于miR-150的进化、生物累积和种间转移的假说
Are We Eating Our Way to Prostate Cancer-A Hypothesis Based on the Evolution, Bioaccumulation, and Interspecific Transfer of miR-150.
作者信息
Vaidyanathan Venkatesh, Krishnamoorthy Vetrivhel, Karunasinghe Nishi, Jabed Anower, Pallati Radha, Kao Chi Hsiu-Juei, Wang Alice, Marlow Gareth, Ferguson Lynnette R
机构信息
Discipline of Nutrition and Dietetics, FM & HS, University of Auckland, Auckland 1023, New Zealand.
Auckland Cancer Society Research Centre, Auckland 1023, New Zealand.
出版信息
Noncoding RNA. 2016 Apr 21;2(2):2. doi: 10.3390/ncrna2020002.
MicroRNAs (miRNAs) are well established epigenetic modifiers. There is a lot of work being done to identify the evolutionary transfer of miRNAs both at intra- and interspecific levels. In this hypothesis-driven review, we have suggested a possible reason as to why miR-150 can be a promising diagnostic biomarker for prostate cancer using theories of evolution, bio-accumulation, and interspecific transfer of miRNAs.
微小RNA（miRNAs）是公认的表观遗传修饰因子。目前正在开展大量工作，以确定miRNAs在种内和种间水平上的进化转移情况。在这篇基于假设的综述中，我们利用miRNAs的进化、生物累积和种间转移理论，提出了一个可能的原因，解释为何miR-150有望成为前列腺癌的诊断生物标志物。
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