Department of Cancer Imaging and Metabolism, Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Exp Mol Med. 2018 Apr 16;50(4):1-16. doi: 10.1038/s12276-018-0027-z.
Cancer cells are highly dependent on metabolic pathways to sustain both their proliferation and adaption to harsh microenvironments. Thus, understanding the metabolic reprogramming that occurs in tumors can provide critical insights for the development of therapies targeting metabolism. In this review, we will discuss recent advancements in metabolomics and other multidisciplinary techniques that have led to the discovery of novel metabolic pathways and mechanisms in diverse cancer types.
癌细胞高度依赖代谢途径来维持增殖和适应恶劣的微环境。因此，了解肿瘤中发生的代谢重编程可以为靶向代谢的治疗方法的开发提供重要的见解。在这篇综述中，我们将讨论代谢组学和其他多学科技术的最新进展，这些进展导致了在不同癌症类型中发现新的代谢途径和机制。
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