Williams Austin D, Payne Kyle K, Posey Avery D, Hill Christine, Conejo-Garcia Jose, June Carl H, Tchou Julia
Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, 10th floor South, Philadelphia, PA 19104, USA.
The Wistar Institute, Philadelphia, PA, USA.
Curr Surg Rep. 2017 Dec;5. doi: 10.1007/s40137-017-0194-1. Epub 2017 Oct 10.
The breast tumor microenvironment is immunosuppressive and is increasingly recognized to play a significant role in tumorigenesis. A deeper understanding of normal and aberrant interactions between malignant and immune cells has allowed researchers to harness the immune system with novel immunotherapy strategies, many of which have shown promise in breast cancer. This review discusses the application of immunotherapy to the treatment of breast cancer.
Both basic science and clinical trial data are rapidly developing in the use of immunotherapy for breast cancer. The current clinical trial landscape includes therapeutic vaccines, immune checkpoint blockade, antibodies, cytokines, and adoptive cell therapy.
Despite early failures, the application of immunotherapeutic strategies to the treatment of breast cancer holds promise.
乳腺肿瘤微环境具有免疫抑制作用，并且越来越被认为在肿瘤发生中起重要作用。对恶性细胞与免疫细胞之间正常和异常相互作用的更深入理解，使研究人员能够利用新型免疫治疗策略来调控免疫系统，其中许多策略已在乳腺癌治疗中显示出前景。本文综述了免疫疗法在乳腺癌治疗中的应用。
在乳腺癌免疫治疗的应用方面，基础科学和临床试验数据都在快速发展。当前的临床试验包括治疗性疫苗、免疫检查点阻断、抗体、细胞因子和过继性细胞治疗。
尽管早期有失败案例，但免疫治疗策略在乳腺癌治疗中的应用仍具有前景。
