几丁质纳米晶体颗粒对人和实验动物血液成分的影响。

Effect of Nanocrystalline Particles of Chitin on Blood Components in Humans and Experimental Animals.

作者信息

Drozd N N, Torlopov M A, Udoratina E V, Logvinova Yu S

机构信息

Hematology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia.

Institute of Chemistry of Komi Research Center, Ural Division of Russian Academy of Science, Syktyvkar, Republic of Komi, Russia.

出版信息

Bull Exp Biol Med. 2018 Apr;164(6):766-769. doi: 10.1007/s10517-018-4076-z. Epub 2018 Apr 16.

DOI:10.1007/s10517-018-4076-z

PMID:29658080

Abstract

Nanocrystalline particles of chitin in the form of hydrosol in a concentration of 0.63 mg/ml have no effect on aggregation of human platelets and clotting time of platelet-poor plasma in coagulation tests. ADP-induced aggregation of human platelets was inhibited by these nanoparticles in concentrations of 0.63 and 1.00 mg/ml in comparison with the control. Intravenous administration of nanoparticles in a dose of 1 mg/kg to guinea pigs produced no anticoagulant effect. The nanocrystalline particles of chitin can be of interest as potential drug delivery systems.

摘要

浓度为0.63毫克/毫升的水溶胶形式的几丁质纳米晶体颗粒，在凝血试验中对人血小板聚集和乏血小板血浆的凝血时间没有影响。与对照组相比，浓度为0.63毫克/毫升和1.00毫克/毫升的这些纳米颗粒抑制了ADP诱导的人血小板聚集。以1毫克/千克的剂量向豚鼠静脉注射纳米颗粒未产生抗凝作用。几丁质纳米晶体颗粒作为潜在的药物递送系统可能会受到关注。