Nordstrom L A, Castaneda-Zuniga W R, Lindeke C C, Rasmussen T M, Burnside D K
Department of Cardiology, Park Nicollet Medical Center, St. Louis Park, MN 55416.
Radiology. 1988 May;167(2):463-5. doi: 10.1148/radiology.167.2.2965818.
A laser catheter system that integrates balloon and fiberoptic technologies was evaluated. In vitro tissue studies were conducted to compare the tissue response to laser irradiation from a bare optical fiber (undiverged light beam) and from a fiber with an optical assembly (diverged light beam). An in vivo study of occluded and unoccluded canine femoral arteries examined coaxial alignment of the diverged light beam and the resultant thermal effects. In the in vitro studies, a diverged laser light beam effected maximum tissue ablation (mean crater diameter, 1.81 mm +/- 0.44) at a distance of only 3 mm from the optical fiber tip. The in vivo study demonstrated the ability of a specially designed balloon catheter to align the diverged laser beam coaxially within the arterial lumen. This laser catheter system successfully avoids the risks of inadequate tissue removal and perforation.
对一种集成了球囊和光纤技术的激光导管系统进行了评估。进行了体外组织研究，以比较裸光纤（未发散光束）和带有光学组件的光纤（发散光束）的激光照射对组织的反应。对闭塞和未闭塞的犬股动脉进行了体内研究，检查了发散光束的同轴对准情况以及由此产生的热效应。在体外研究中，发散的激光束在距光纤尖端仅3毫米的距离处实现了最大组织消融（平均弹坑直径，1.81毫米±0.44）。体内研究证明了一种特殊设计的球囊导管能够在动脉腔内将发散的激光束同轴对准。这种激光导管系统成功避免了组织切除不足和穿孔的风险。
