Zheng Cai-Juan, Liao Hai-Xia, Mei Rong-Qing, Huang Guo-Lei, Yang Lu-Jia, Zhou Xue-Ming, Shao Tai-Ming, Chen Guang-Ying, Wang Chang-Yun
a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering , Hainan Normal University , Haikou , P. R. China.
b Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P. R. China.
Nat Prod Res. 2019 Apr;33(8):1127-1134. doi: 10.1080/14786419.2018.1460832. Epub 2018 Apr 15.
Two new compounds penibenzophenones A-B (1-2), and the synthetic α,β-unsaturated amide alkaloid (E)-tert-butyl(3-cinnamamidopropyl)carbamate (4), newly identified as a natural product, alone with three known ones (3, 5-6) were isolated from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Compound 1 was a chlorinated benzophenone. The structures of 1-6 were elucidated by extensive NMR spectral interpretation, MS data and X-ray analysis. The new compound 2 displayed cytotoxic activity against human A549 cell lines with an IC value of 15.7 μg/mL, and 1 showed antibacterial activity against Staphylococcus aureus with a MIC value of 20 μg/mL.
从采自中国南海的红树植物尖瓣海莲（Bruguiera sexangula var. rhynchopetala）中分离得到的内生真菌桔青霉（Penicillium citrinum）HL-5126的乙酸乙酯提取物中，分离出了两种新化合物苯甲酮青霉素A - B（1 - 2），以及一种新鉴定为天然产物的合成α,β - 不饱和酰胺生物碱（E）-叔丁基（3 - 肉桂酰胺基丙基）氨基甲酸酯（4），还有三种已知化合物（3、5 - 6）。化合物1是一种氯化苯甲酮。通过广泛的核磁共振光谱解析、质谱数据和X射线分析确定了1 - 6的结构。新化合物2对人A549细胞系具有细胞毒性活性，IC值为15.7 μg/mL，化合物1对金黄色葡萄球菌具有抗菌活性，MIC值为20 μg/mL。
