Lyu Can, Qu Yi, Mu De-Zhi
Department of Pediatrics, West China Second University Hospital/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2018 Apr;20(4):338-340. doi: 10.7499/j.issn.1008-8830.2018.04.016.
Preterm infants are a special group, and related severe neurological, respiratory, and digestive disorders have high disability/fatality rates. Allogeneic cell transplantation may be an effective method for the prevention and treatment of these diseases. At present, animal studies have been conducted for allogeneic cell transplantation in the treatment of hypoxic-ischemic encephalopathy, bronchopulmonary dysplasia, and necrotizing enterocolitis. The main difficulty of this technique is graft-versus-host reaction (GVHR), and successful induction of immune tolerance needs to be achieved in order to solve this problem. This article reviews the research advances in immune tolerance of allogeneic cell transplantation in preterm infants.
早产儿是一个特殊群体，与之相关的严重神经、呼吸和消化系统疾病具有较高的致残率/死亡率。异基因细胞移植可能是预防和治疗这些疾病的有效方法。目前，已经开展了异基因细胞移植治疗缺氧缺血性脑病、支气管肺发育不良和坏死性小肠结肠炎的动物研究。这项技术的主要难点是移植物抗宿主反应（GVHR），需要成功诱导免疫耐受以解决这一问题。本文综述了早产儿异基因细胞移植免疫耐受的研究进展。
