McGlashan E M, Drummond S P A, Cain S W
a Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University , Melbourne , VIC , Australia.
Chronobiol Int. 2018 Aug;35(8):1175-1178. doi: 10.1080/07420528.2018.1458316. Epub 2018 Apr 16.
Selective serotonin reuptake inhibitors (SSRIs) have a profound effect on the circadian system's response to environmental light, which may impact treatment outcomes for patients depending on their habitual light exposure patterns. Here, we investigated the relationship between time-of-day preference, depressive symptoms and self-reported antidepressant treatment response. Evening types reported having taken a higher number of antidepressant medications in the previous 5 years and lower SSRI efficacy than morning types. While undergoing SSRI treatment, evening types also reported more depressive symptoms and suicidality. It is concluded that time-of-day preference may prove informative in predicting SSRI treatment responses.
选择性5-羟色胺再摄取抑制剂（SSRI）对昼夜节律系统对环境光线的反应有深远影响，这可能会根据患者的习惯性光照暴露模式影响治疗效果。在此，我们研究了一天中时间偏好、抑郁症状与自我报告的抗抑郁治疗反应之间的关系。与早晨型的人相比，夜晚型的人报告称在过去5年中服用的抗抑郁药物数量更多，且SSRI疗效更低。在接受SSRI治疗期间，夜晚型的人还报告有更多的抑郁症状和自杀倾向。结论是，一天中时间偏好可能在预测SSRI治疗反应方面具有参考价值。
