Ekholm S, Simon J H
Department of Radiology, University of Rochester Medical Center, New York 14642.
Acta Radiol. 1988 Mar-Apr;29(2):227-30.
It is now recognized that patients infected by the virus linked to the acquired immunodeficiency syndrome (AIDS) can develop dementia symptoms as the initial and sometimes only symptomatology for AIDS. This appears to be a syndrome whose origin is independent of secondary non-viral infection or malignancy. Magnetic resonance imaging (MRI) in three patients with well documented AIDS dementia revealed high signal periventricular white matter lesions. In one case, large lesions were not apparent on computed tomography and gross inspection of the fixed brain prior to autopsy. In two cases in which serial in vivo MR studies were obtained, there was a progressive increase in lesion volume over a short (several months) period of observation. Periventricular white matter lesions may be an early sign accompanying AIDS dementia, and the degree of changes correlated well with the clinical picture in our patients.
现在已经认识到，感染与获得性免疫缺陷综合征（艾滋病）相关病毒的患者可能会出现痴呆症状，作为艾滋病的初始症状，有时甚至是唯一症状。这似乎是一种起源独立于继发性非病毒感染或恶性肿瘤的综合征。对三名有充分记录的艾滋病痴呆患者进行的磁共振成像（MRI）显示，脑室周围白质有高信号病变。在一个病例中，计算机断层扫描和尸检前对固定大脑的大体检查均未发现大的病变。在另外两个进行了系列活体磁共振研究的病例中，在短（几个月）观察期内病变体积逐渐增加。脑室周围白质病变可能是艾滋病痴呆伴随的早期迹象，并且变化程度与我们患者的临床表现密切相关。
