a College of Pharmacy , The University of Texas at Austin , Austin , TX , USA.
b Department of Communication Sciences and Disorders , The University of Texas at Austin , Austin , TX , USA.
Drug Dev Ind Pharm. 2018 Sep;44(9):1395-1408. doi: 10.1080/03639045.2018.1464022. Epub 2018 Apr 25.
Disorders of the ear severely impact the quality of life of millions of people, but the treatment of these disorders is an ongoing, but often overlooked challenge particularly in terms of formulation design and product development. The prevalence of ear disorders has spurred significant efforts to develop new therapeutic agents, but perhaps less innovation has been applied to new drug delivery systems to improve the efficacy of ear disease treatments. This review provides a brief overview of physiology, major diseases, and current therapies used via the otic route of administration. The primary focuses are on the various administration routes and their formulation principles. The article also presents recent advances in otic drug deliveries as well as potential limitations. Otic drug delivery technology will likely evolve in the next decade and more efficient or specific treatments for ear disease will arise from the development of less invasive drug delivery methods, safe and highly controlled drug delivery systems, and biotechnology targeting therapies.
耳部疾病严重影响着数百万人的生活质量，但这些疾病的治疗是一个持续存在但往往被忽视的挑战，尤其是在制剂设计和产品开发方面。耳部疾病的高发率促使人们大力开发新的治疗药物，但在提高耳部疾病治疗效果的新药物传递系统方面的创新可能较少。本文简要概述了耳生理学、主要疾病以及通过耳途径给药的当前治疗方法。主要重点是各种给药途径及其制剂原理。本文还介绍了最近在耳部药物传递方面的进展以及潜在的局限性。在未来十年，耳部药物输送技术可能会不断发展，通过开发更具侵袭性的药物输送方法、安全且高度受控的药物输送系统以及针对生物技术的靶向治疗，将出现治疗耳部疾病的更有效或更具针对性的治疗方法。
