Zhang Zipei, Li Xiyu, Zhang Wei, Kohane Daniel S
Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Adv Funct Mater. 2021 Oct 26;31(44). doi: 10.1002/adfm.202008701. Epub 2020 Dec 4.
The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat these conditions. Here, recent advances in drug delivery systems that access the ear through the tympanic membrane (TM) are reviewed. Such methods are either non-invasive (placed on the surface of the TM), or invasive (placed in the middle ear, ideally on the round window [RW]). The major hurdles to otic drug delivery are identified and highlighted the representative examples of drug delivery systems used for drug delivery across the TM to the middle and (crossing the RW also) inner ear.
耳部疾病的高发病率促使人们努力开发药物递送系统来治疗这些病症。在此，对通过鼓膜（TM）进入耳部的药物递送系统的最新进展进行综述。此类方法要么是非侵入性的（置于TM表面），要么是侵入性的（置于中耳，理想情况下置于圆窗[RW]上）。确定了耳部药物递送的主要障碍，并重点介绍了用于通过TM向中耳和（也穿过RW）内耳递送药物的药物递送系统的代表性实例。
