Dietl M M, Palacios J M
Preclinical Research, Sandoz Ltd., Basle, Switzerland.
Brain Res. 1988 Jan 26;439(1-2):354-9. doi: 10.1016/0006-8993(88)91494-1.
The distribution of dopamine D1 and D2 receptors was investigated in the pigeon brain using in vitro receptor autoradiography. D1 receptors were labeled in slide-mounted tissue sections with [3H]SCH 23390. The agonist [3H]CV 205-502 and the antagonist [3H]spiroperidol were used to label D2 receptors. The highest densities of both D1 and D2 receptors were concentrated in the paleostriatum augmentatum, lobus paraolfactorius and olfactory tubercle. D1 receptors were in addition enriched in the entire pigeon telencephalon with exception of the ectostriatum. In contrast, no significant densities of D2 receptors were observed in the pallium. D2 but not D1 receptors were present in the tectum and nucleus pretectalis. The cerebellum presented D1 but not D2 receptors. These results demonstrate that in the avian brain, like in the mammalian one, both dopamine D1 and D2 receptors are concentrated in 'striatal' areas, while the telencephalon is rich in D1 but not D2 receptors.
采用体外受体放射自显影技术研究了鸽子脑中多巴胺D1和D2受体的分布情况。用[3H]SCH 23390对载玻片上的组织切片中的D1受体进行标记。激动剂[3H]CV 205 - 502和拮抗剂[3H]螺哌啶醇用于标记D2受体。D1和D2受体的最高密度都集中在古纹状体增大部、嗅旁叶和嗅结节。此外，除了外纹状体，整个鸽子端脑的D1受体都很丰富。相比之下，在大脑皮层未观察到明显的D2受体密度。中脑顶盖和顶盖前核存在D2受体而非D1受体。小脑存在D1受体而非D2受体。这些结果表明，在鸟类大脑中，与哺乳动物大脑一样，多巴胺D1和D2受体都集中在“纹状体”区域，而端脑富含D1受体但不含D2受体。
